Title |
Vascular regulation of adult neurogenesis under physiological and pathological conditions
|
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Published in |
Frontiers in Neuroscience, March 2014
|
DOI | 10.3389/fnins.2014.00053 |
Pubmed ID | |
Authors |
Masato Sawada, Mami Matsumoto, Kazunobu Sawamoto |
Abstract |
Neural stem cells in the mammalian adult brain continuously produce new neurons throughout life. Accumulating evidence in rodents suggests that various aspects of adult neurogenesis, including the genesis, migration, and maturation of new neurons, are regulated by factors derived from blood vessels and their microenvironment. Brain injury enhances both neurogenesis and angiogenesis, thereby promoting the cooperative regeneration of neurons and blood vessels. In this paper, we briefly review the mechanisms for the vascular regulation of adult neurogenesis in the ventricular-subventricular zone under physiological and pathological conditions, and discuss their clinical potential for brain regeneration strategies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 2% |
Spain | 1 | 1% |
Russia | 1 | 1% |
Germany | 1 | 1% |
Unknown | 83 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 19% |
Researcher | 17 | 19% |
Student > Master | 16 | 18% |
Student > Bachelor | 7 | 8% |
Student > Doctoral Student | 7 | 8% |
Other | 12 | 14% |
Unknown | 12 | 14% |
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Agricultural and Biological Sciences | 24 | 27% |
Neuroscience | 22 | 25% |
Biochemistry, Genetics and Molecular Biology | 11 | 13% |
Medicine and Dentistry | 11 | 13% |
Engineering | 4 | 5% |
Other | 2 | 2% |
Unknown | 14 | 16% |