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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A comprehensive assessment of resting state networks: bidirectional modification of functional integrity in cerebro-cerebellar networks in dementia
|
|---|---|
| Published in |
Frontiers in Neuroscience, July 2014
|
| DOI | 10.3389/fnins.2014.00223 |
| Pubmed ID | |
| Authors |
Gloria Castellazzi, Fulvia Palesi, Stefano Casali, Paolo Vitali, Elena Sinforiani, Claudia A. M. Wheeler-Kingshott, Egidio D'Angelo |
| Abstract |
In resting state fMRI (rs-fMRI), only functional connectivity (FC) reductions in the default mode network (DMN) are normally reported as a biomarker for Alzheimer's disease (AD). In this investigation we have developed a comprehensive strategy to characterize the FC changes occurring in multiple networks and applied it in a pilot study of subjects with AD and Mild Cognitive Impairment (MCI), compared to healthy controls (HC). Resting state networks (RSNs) were studied in 14 AD (70 ± 6 years), 12 MCI (74 ± 6 years), and 16 HC (69 ± 5 years). RSN alterations were present in almost all the 15 recognized RSNs; overall, 474 voxels presented a reduced FC in MCI and 1244 in AD while 1627 voxels showed an increased FC in MCI and 1711 in AD. The RSNs were then ranked according to the magnitude and extension of FC changes (gFC), putting in evidence 6 RSNs with prominent changes: DMN, frontal cortical network (FCN), lateral visual network (LVN), basal ganglia network (BGN), cerebellar network (CBLN), and the anterior insula network (AIN). Nodes, or hubs, showing alterations common to more than one RSN were mostly localized within the prefrontal cortex and the mesial-temporal cortex. The cerebellum showed a unique behavior where voxels of decreased gFC were only found in AD while a significant gFC increase was only found in MCI. The gFC alterations showed strong correlations (p < 0.001) with psychological scores, in particular Mini-Mental State Examination (MMSE) and attention/memory tasks. In conclusion, this analysis revealed that the DMN was affected by remarkable FC increases, that FC alterations extended over several RSNs, that derangement of functional relationships between multiple areas occurred already in the early stages of dementia. These results warrant future work to verify whether these represent compensatory mechanisms that exploit a pre-existing neural reserve through plasticity, which evolve in a state of lack of connectivity between different networks with the worsening of the pathology. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 2% |
| India | 1 | <1% |
| United Kingdom | 1 | <1% |
| Belgium | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 131 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 22% |
| Student > Ph. D. Student | 25 | 18% |
| Student > Master | 18 | 13% |
| Student > Bachelor | 10 | 7% |
| Student > Postgraduate | 9 | 7% |
| Other | 17 | 12% |
| Unknown | 29 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 31 | 22% |
| Psychology | 24 | 17% |
| Medicine and Dentistry | 15 | 11% |
| Agricultural and Biological Sciences | 10 | 7% |
| Computer Science | 6 | 4% |
| Other | 18 | 13% |
| Unknown | 34 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 August 2014.
All research outputs
#13,917,225
of 22,759,618 outputs
Outputs from Frontiers in Neuroscience
#5,956
of 9,874 outputs
Outputs of similar age
#114,615
of 228,682 outputs
Outputs of similar age from Frontiers in Neuroscience
#62
of 123 outputs
Altmetric has tracked 22,759,618 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,874 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.1. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,682 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 123 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.