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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Golgi fragmentation in Alzheimer's disease
|
|---|---|
| Published in |
Frontiers in Neuroscience, September 2015
|
| DOI | 10.3389/fnins.2015.00340 |
| Pubmed ID | |
| Authors |
Gunjan Joshi, Michael E. Bekier, Yanzhuang Wang |
| Abstract |
The Golgi apparatus is an essential cellular organelle for post-translational modifications, sorting, and trafficking of membrane and secretory proteins. Proper functionality of the Golgi requires the formation of its unique cisternal-stacking morphology. The Golgi structure is disrupted in a variety of neurodegenerative diseases, suggesting a common mechanism and contribution of Golgi defects in neurodegenerative disorders. A recent study on Alzheimer's disease (AD) revealed that phosphorylation of the Golgi stacking protein GRASP65 disrupts its function in Golgi structure formation, resulting in Golgi fragmentation. Inhibiting GRASP65 phosphorylation restores the Golgi morphology from Aβ-induced fragmentation and reduces Aβ production. Perturbing Golgi structure and function in neurons may directly impact trafficking, processing, and sorting of a variety of proteins essential for synaptic and dendritic integrity. Therefore, Golgi defects may ultimately promote the development of AD. In the current review, we focus on the cellular impact of impaired Golgi morphology and its potential relationship to AD disease development. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 132 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 20% |
| Student > Master | 22 | 17% |
| Researcher | 12 | 9% |
| Student > Bachelor | 11 | 8% |
| Student > Doctoral Student | 4 | 3% |
| Other | 10 | 8% |
| Unknown | 47 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 27 | 20% |
| Agricultural and Biological Sciences | 22 | 17% |
| Neuroscience | 12 | 9% |
| Medicine and Dentistry | 6 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Other | 12 | 9% |
| Unknown | 50 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2022.
All research outputs
#2,314,740
of 25,374,917 outputs
Outputs from Frontiers in Neuroscience
#1,379
of 11,541 outputs
Outputs of similar age
#31,086
of 285,941 outputs
Outputs of similar age from Frontiers in Neuroscience
#14
of 154 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,541 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,941 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 154 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.