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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Synaptic activity and Alzheimer's disease: a critical update
|
|---|---|
| Published in |
Frontiers in Neuroscience, November 2015
|
| DOI | 10.3389/fnins.2015.00423 |
| Pubmed ID | |
| Authors |
Davide Tampellini |
| Abstract |
Synapses have been known for many years to be the crucial target of pathology in different forms of dementia, in particular Alzheimer's disease (AD). Synapses and their appropriate activation or inhibition are fundamental for the proper brain function. Alterations in synaptic/neuronal activity and brain metabolism are considered among the earliest symptoms linked to the progression of AD, and lead to a central question in AD research: what is the role played by synaptic activity in AD pathogenesis? Intriguingly, in the last decade, important studies demonstrated that the state of activation of synapses affects the homeostasis of beta-amyloid (Aβ) and tau, both of which aggregate and accumulate during AD, and are involved in neuronal dysfunction. In this review we aim to summarize the up-to-date data linking synaptic/neuronal activity with Aβ and tau; moreover, we also intend to provide a critical overview on brain activity alterations in AD, and their role in the disease's pathophysiology. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 29% |
| Unknown | 5 | 71% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 57% |
| Practitioners (doctors, other healthcare professionals) | 2 | 29% |
| Scientists | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 119 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 29 | 24% |
| Student > Bachelor | 21 | 17% |
| Student > Ph. D. Student | 19 | 16% |
| Student > Master | 17 | 14% |
| Professor > Associate Professor | 5 | 4% |
| Other | 16 | 13% |
| Unknown | 14 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 39 | 32% |
| Agricultural and Biological Sciences | 25 | 21% |
| Biochemistry, Genetics and Molecular Biology | 18 | 15% |
| Medicine and Dentistry | 6 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
| Other | 10 | 8% |
| Unknown | 18 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2016.
All research outputs
#7,896,290
of 25,373,627 outputs
Outputs from Frontiers in Neuroscience
#5,007
of 11,538 outputs
Outputs of similar age
#92,728
of 296,794 outputs
Outputs of similar age from Frontiers in Neuroscience
#64
of 154 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 11,538 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 296,794 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 154 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.