Title |
Mechanisms and Functional Significance of Stroke-Induced Neurogenesis
|
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Published in |
Frontiers in Neuroscience, December 2015
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DOI | 10.3389/fnins.2015.00458 |
Pubmed ID | |
Authors |
Quentin Marlier, Sebastien Verteneuil, Renaud Vandenbosch, Brigitte Malgrange |
Abstract |
Stroke affects one in every six people worldwide, and is the leading cause of adult disability. After stroke, some limited spontaneous recovery occurs, the mechanisms of which remain largely unknown. Multiple, parallel approaches are being investigated to develop neuroprotective, reparative and regenerative strategies for the treatment of stroke. For years, clinical studies have tried to use exogenous cell therapy as a means of brain repair, with varying success. Since the rediscovery of adult neurogenesis and the identification of adult neural stem cells in the late nineties, one promising field of investigation is focused upon triggering and stimulating this self-repair system to replace the neurons lost following brain injury. For instance, it is has been demonstrated that the adult brain has the capacity to produce large numbers of new neurons in response to stroke. The purpose of this review is to provide an updated overview of stroke-induced adult neurogenesis, from a cellular and molecular perspective, to its impact on brain repair and functional recovery. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 33% |
Switzerland | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | <1% |
Mexico | 1 | <1% |
United States | 1 | <1% |
Portugal | 1 | <1% |
Unknown | 134 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 28 | 20% |
Student > Ph. D. Student | 24 | 17% |
Researcher | 23 | 17% |
Student > Master | 15 | 11% |
Student > Doctoral Student | 10 | 7% |
Other | 17 | 12% |
Unknown | 21 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 39 | 28% |
Medicine and Dentistry | 28 | 20% |
Agricultural and Biological Sciences | 20 | 14% |
Biochemistry, Genetics and Molecular Biology | 12 | 9% |
Psychology | 6 | 4% |
Other | 9 | 7% |
Unknown | 24 | 17% |