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X Demographics
Mendeley readers
Attention Score in Context
| Title |
CB2 Cannabinoid Receptor As Potential Target against Alzheimer's Disease
|
|---|---|
| Published in |
Frontiers in Neuroscience, May 2016
|
| DOI | 10.3389/fnins.2016.00243 |
| Pubmed ID | |
| Authors |
Ester Aso, Isidro Ferrer |
| Abstract |
The CB2 receptor is one of the components of the endogenous cannabinoid system, a complex network of signaling molecules and receptors involved in the homeostatic control of several physiological functions. Accumulated evidence suggests a role for CB2 receptors in Alzheimer's disease (AD) and indicates their potential as a therapeutic target against this neurodegenerative disease. Levels of CB2 receptors are significantly increased in post-mortem AD brains, mainly in microglia surrounding senile plaques, and their expression levels correlate with the amounts of Aβ42 and β-amyloid plaque deposition. Moreover, several studies on animal models of AD have demonstrated that specific CB2 receptor agonists, which are devoid of psychoactive effects, reduce AD-like pathology, resulting in attenuation of the inflammation associated with the disease but also modulating Aβ and tau aberrant processing, among other effects. CB2 receptor activation also improves cognitive impairment in animal models of AD. This review discusses available data regarding the role of CB2 receptors in AD and the potential usefulness of specific agonists of these receptors against AD. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 18% |
| United States | 2 | 18% |
| New Zealand | 1 | 9% |
| Unknown | 6 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 82% |
| Practitioners (doctors, other healthcare professionals) | 2 | 18% |
Mendeley readers
The data shown below were compiled from readership statistics for 252 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 250 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 37 | 15% |
| Student > Master | 34 | 13% |
| Researcher | 32 | 13% |
| Student > Ph. D. Student | 29 | 12% |
| Student > Doctoral Student | 10 | 4% |
| Other | 35 | 14% |
| Unknown | 75 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 35 | 14% |
| Biochemistry, Genetics and Molecular Biology | 30 | 12% |
| Neuroscience | 28 | 11% |
| Agricultural and Biological Sciences | 17 | 7% |
| Chemistry | 15 | 6% |
| Other | 41 | 16% |
| Unknown | 86 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 July 2023.
All research outputs
#1,929,552
of 25,371,288 outputs
Outputs from Frontiers in Neuroscience
#1,039
of 11,538 outputs
Outputs of similar age
#33,943
of 353,666 outputs
Outputs of similar age from Frontiers in Neuroscience
#25
of 178 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,538 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,666 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 178 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.