Title |
Oxidative Stress Modifies the Levels and Phosphorylation State of Tau Protein in Human Fibroblasts
|
---|---|
Published in |
Frontiers in Neuroscience, September 2017
|
DOI | 10.3389/fnins.2017.00495 |
Pubmed ID | |
Authors |
Alejandro Ibáñez-Salazar, Bernardo Bañuelos-Hernández, Ildefonso Rodríguez-Leyva, Erika Chi-Ahumada, Elizabeth Monreal-Escalante, María E. Jiménez-Capdeville, Sergio Rosales-Mendoza |
Abstract |
Since the tau protein is closely involved in the physiopathology of Alzheimer's disease (AD), studying its behavior in cellular models might lead to new insights on understanding this devastating disease at molecular levels. In the present study, primary cultures of human fibroblasts were established and used to determine the expression and localization of the tau protein in distinct phosphorylation states in both untransfected and tau gene-transfected cells subjected to oxidative stress. Higher immunopositivity to phospho-tau was observed in cell nuclei in response to oxidative stress, while the levels of total tau in the cytosol remained unchanged. These findings were observed in both untransfected cells and those transfected with the tau gene. The present work represents a useful model for studying the physiopathology of AD at the cellular level in terms of tau protein implications. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 55 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 22% |
Student > Master | 7 | 13% |
Student > Bachelor | 7 | 13% |
Professor | 6 | 11% |
Unspecified | 5 | 9% |
Other | 8 | 15% |
Unknown | 10 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 10 | 18% |
Neuroscience | 9 | 16% |
Agricultural and Biological Sciences | 6 | 11% |
Unspecified | 6 | 11% |
Materials Science | 2 | 4% |
Other | 12 | 22% |
Unknown | 10 | 18% |