The data shown below were collected from the profiles of 39 X users who shared this research output. Click here to find out more about how the information was compiled.
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Implantation of 3D Constructs Embedded with Oral Mucosa-Derived Cells Induces Functional Recovery in Rats with Complete Spinal Cord Transection
|
|---|---|
| Published in |
Frontiers in Neuroscience, October 2017
|
| DOI | 10.3389/fnins.2017.00589 |
| Pubmed ID | |
| Authors |
Javier Ganz, Erez Shor, Shaowei Guo, Anton Sheinin, Ina Arie, Izhak Michaelevski, Sandu Pitaru, Daniel Offen, Shulamit Levenberg |
| Abstract |
Spinal cord injury (SCI), involving damaged axons and glial scar tissue, often culminates in irreversible impairments. Achieving substantial recovery following complete spinal cord transection remains an unmet challenge. Here, we report of implantation of an engineered 3D construct embedded with human oral mucosa stem cells (hOMSC) induced to secrete neuroprotective, immunomodulatory, and axonal elongation-associated factors, in a complete spinal cord transection rat model. Rats implanted with induced tissue engineering constructs regained fine motor control, coordination and walking pattern in sharp contrast to the untreated group that remained paralyzed (42 vs. 0%). Immunofluorescence, CLARITY, MRI, and electrophysiological assessments demonstrated a reconnection bridging the injured area, as well as presence of increased number of myelinated axons, neural precursors, and reduced glial scar tissue in recovered animals treated with the induced cell-embedded constructs. Finally, this construct is made of bio-compatible, clinically approved materials and utilizes a safe and easily extractable cell population. The results warrant further research with regards to the effectiveness of this treatment in addressing spinal cord injury. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 5 | 13% |
| United States | 5 | 13% |
| Switzerland | 1 | 3% |
| Spain | 1 | 3% |
| United Kingdom | 1 | 3% |
| Germany | 1 | 3% |
| Unknown | 25 | 64% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 31 | 79% |
| Scientists | 6 | 15% |
| Practitioners (doctors, other healthcare professionals) | 2 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 68 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 15% |
| Student > Master | 8 | 12% |
| Student > Bachelor | 7 | 10% |
| Researcher | 4 | 6% |
| Librarian | 3 | 4% |
| Other | 11 | 16% |
| Unknown | 25 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 13% |
| Engineering | 8 | 12% |
| Agricultural and Biological Sciences | 5 | 7% |
| Medicine and Dentistry | 5 | 7% |
| Neuroscience | 4 | 6% |
| Other | 7 | 10% |
| Unknown | 30 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 155. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2022.
All research outputs
#264,077
of 25,382,440 outputs
Outputs from Frontiers in Neuroscience
#116
of 11,542 outputs
Outputs of similar age
#5,516
of 340,266 outputs
Outputs of similar age from Frontiers in Neuroscience
#3
of 188 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,542 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,266 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 188 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.