Shu-Hong Jia, Kai Li, Wen Su, Shu-Hua Li, Hai-Bo Chen
Abstract
Objective: Patients with Parkinson's disease have prospective memory impairments. However, little is known about distinct phases of prospective memory in these patients. This study was designed to elucidate the specific phase(s) of prospective memory that are impaired in patients with Parkinson's disease. Methods: The study included 31 Parkinson's disease patients and 27 healthy controls. The four phases of prospective memory (intention formation, retention, initiation, and execution) were examined in a complex prospective memory task. In this task, the participants were asked to form a sophisticated plan for performing six subtasks to obtain the highest score, and then execute the plan following a cue embedded in a questionnaire. Global cognitive function and relevant cognitive abilities, including attention, short-term memory, working memory, and inhibition, were also evaluated during the retention phase of the prospective memory task. Results: Intention formation was impaired in Parkinson's disease patients (p < 0.001 vs. healthy controls). This impairment could not be attributed to deficits in other cognitive functions. The score of intention execution was also lower in Parkinson's disease patients (p = 0.004 vs. healthy controls). Such a difference was related to working memory deficits in Parkinson's disease. The intention retention and initiation were intact in Parkinson's disease patients. The score of intention execution correlated negatively with disease severity and disease duration. Conclusions: Prospective memory in Parkinson's disease patients is impaired at the phase of intention formation. The worsening performance of intention execution in Parkinson's disease may be related to working memory deficits. In addition, prospective memory impairment might progress with increasing disease duration and severity.
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2018.
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#40
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Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,542 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done well, scoring higher than 88% of its peers.
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