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Analysis of Vestibular Labyrinthine Geometry and Variation in the Human Temporal Bone

Overview of attention for article published in Frontiers in Neuroscience, February 2018
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Title
Analysis of Vestibular Labyrinthine Geometry and Variation in the Human Temporal Bone
Published in
Frontiers in Neuroscience, February 2018
DOI 10.3389/fnins.2018.00107
Pubmed ID
Authors

Lejo Johnson Chacko, Dominik T. Schmidbauer, Stephan Handschuh, Alen Reka, Karl D. Fritscher, Patrik Raudaschl, Rami Saba, Michael Handler, Peter P. Schier, Daniel Baumgarten, Natalie Fischer, Elisabeth J. Pechriggl, Erich Brenner, Romed Hoermann, Rudolf Glueckert, Anneliese Schrott-Fischer

Abstract

Stable posture and body movement in humans is dictated by the precise functioning of the ampulla organs in the semi-circular canals. Statistical analysis of the interrelationship between bony and membranous compartments within the semi-circular canals is dependent on the visualization of soft tissue structures. Thirty-one human inner ears were prepared, post-fixed with osmium tetroxide and decalcified for soft tissue contrast enhancement. High resolution X-ray microtomography images at 15 μm voxel-size were manually segmented. This data served as templates for centerline generation and cross-sectional area extraction. Our estimates demonstrate the variability of individual specimens from averaged centerlines of both bony and membranous labyrinth. Centerline lengths and cross-sectional areas along these lines were identified from segmented data. Using centerlines weighted by the inverse squares of the cross-sectional areas, plane angles could be quantified. The fit planes indicate that the bony labyrinth resembles a Cartesian coordinate system more closely than the membranous labyrinth. A widening in the membranous labyrinth of the lateral semi-circular canal was observed in some of the specimens. Likewise, the cross-sectional areas in the perilymphatic spaces of the lateral canal differed from the other canals. For the first time we could precisely describe the geometry of the human membranous labyrinth based on a large sample size. Awareness of the variations in the canal geometry of the membranous and bony labyrinth would be a helpful reference in designing electrodes for future vestibular prosthesis and simulating fluid dynamics more precisely.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 50 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 20%
Student > Master 6 12%
Student > Ph. D. Student 4 8%
Professor > Associate Professor 4 8%
Student > Bachelor 3 6%
Other 8 16%
Unknown 15 30%
Readers by discipline Count As %
Medicine and Dentistry 9 18%
Engineering 7 14%
Neuroscience 6 12%
Agricultural and Biological Sciences 4 8%
Unspecified 3 6%
Other 5 10%
Unknown 16 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2018.
All research outputs
#19,951,180
of 25,382,440 outputs
Outputs from Frontiers in Neuroscience
#8,672
of 11,542 outputs
Outputs of similar age
#253,053
of 343,860 outputs
Outputs of similar age from Frontiers in Neuroscience
#201
of 242 outputs
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