Title |
Analysis of Vestibular Labyrinthine Geometry and Variation in the Human Temporal Bone
|
---|---|
Published in |
Frontiers in Neuroscience, February 2018
|
DOI | 10.3389/fnins.2018.00107 |
Pubmed ID | |
Authors |
Lejo Johnson Chacko, Dominik T. Schmidbauer, Stephan Handschuh, Alen Reka, Karl D. Fritscher, Patrik Raudaschl, Rami Saba, Michael Handler, Peter P. Schier, Daniel Baumgarten, Natalie Fischer, Elisabeth J. Pechriggl, Erich Brenner, Romed Hoermann, Rudolf Glueckert, Anneliese Schrott-Fischer |
Abstract |
Stable posture and body movement in humans is dictated by the precise functioning of the ampulla organs in the semi-circular canals. Statistical analysis of the interrelationship between bony and membranous compartments within the semi-circular canals is dependent on the visualization of soft tissue structures. Thirty-one human inner ears were prepared, post-fixed with osmium tetroxide and decalcified for soft tissue contrast enhancement. High resolution X-ray microtomography images at 15 μm voxel-size were manually segmented. This data served as templates for centerline generation and cross-sectional area extraction. Our estimates demonstrate the variability of individual specimens from averaged centerlines of both bony and membranous labyrinth. Centerline lengths and cross-sectional areas along these lines were identified from segmented data. Using centerlines weighted by the inverse squares of the cross-sectional areas, plane angles could be quantified. The fit planes indicate that the bony labyrinth resembles a Cartesian coordinate system more closely than the membranous labyrinth. A widening in the membranous labyrinth of the lateral semi-circular canal was observed in some of the specimens. Likewise, the cross-sectional areas in the perilymphatic spaces of the lateral canal differed from the other canals. For the first time we could precisely describe the geometry of the human membranous labyrinth based on a large sample size. Awareness of the variations in the canal geometry of the membranous and bony labyrinth would be a helpful reference in designing electrodes for future vestibular prosthesis and simulating fluid dynamics more precisely. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 50 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 20% |
Student > Master | 6 | 12% |
Student > Ph. D. Student | 4 | 8% |
Professor > Associate Professor | 4 | 8% |
Student > Bachelor | 3 | 6% |
Other | 8 | 16% |
Unknown | 15 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 18% |
Engineering | 7 | 14% |
Neuroscience | 6 | 12% |
Agricultural and Biological Sciences | 4 | 8% |
Unspecified | 3 | 6% |
Other | 5 | 10% |
Unknown | 16 | 32% |