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Annexin A7 Levels Increase in Rats With Traumatic Brain Injury and Promote Secondary Brain Injury

Overview of attention for article published in Frontiers in Neuroscience, May 2018
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Title
Annexin A7 Levels Increase in Rats With Traumatic Brain Injury and Promote Secondary Brain Injury
Published in
Frontiers in Neuroscience, May 2018
DOI 10.3389/fnins.2018.00357
Pubmed ID
Authors

Fan Gao, Di Li, Qin Rui, Haibo Ni, Huixiang Liu, Feng Jiang, Li Tao, Rong Gao, Baoqi Dang

Abstract

The incidence of traumatic brain injury (TBI) has been increasing annually. Annexin A7 is a calcium-dependent phospholipid binding protein. It can promote melting of the cell membrane. Recent studies have shown that it plays an important role in atherosclerosis, other cardiovascular diseases, and a variety of tumors. However, few studies of ANXA7 in TBI have been performed. We here observed how ANXA7 changes after TBI and discuss whether brain injury is associated with the use of ANXA7 antagonist intervention. Experimental Results: 1. After TBI, ANXA7 levels were higher than in the sham group, peaking 24 h after TBI. 2. The use of siA7 was found to reduce the expression of A7 in the injured brain tissue, and also brain edema, BBB damage, cell death, and apoptosis relative to the sham group. Conclusion: ANXA7 promotes the development of secondary brain injury (SBI) after TBI.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 30%
Professor 1 10%
Student > Ph. D. Student 1 10%
Student > Master 1 10%
Researcher 1 10%
Other 0 0%
Unknown 3 30%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 1 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 10%
Biochemistry, Genetics and Molecular Biology 1 10%
Psychology 1 10%
Chemistry 1 10%
Other 1 10%
Unknown 4 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2018.
All research outputs
#17,292,294
of 25,382,440 outputs
Outputs from Frontiers in Neuroscience
#8,070
of 11,542 outputs
Outputs of similar age
#222,675
of 344,685 outputs
Outputs of similar age from Frontiers in Neuroscience
#184
of 234 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,542 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,685 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 234 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.