Title |
Stress-Induced Functional Alterations in Amygdala: Implications for Neuropsychiatric Diseases
|
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Published in |
Frontiers in Neuroscience, May 2018
|
DOI | 10.3389/fnins.2018.00367 |
Pubmed ID | |
Authors |
Xin Zhang, Tong tong Ge, Guanghao Yin, Ranji Cui, Guoqing Zhao, Wei Yang |
Abstract |
The amygdala plays a major role in the processing of physiologic and behavioral responses to stress and is characterized by gamma-aminobutyric acid (GABA)-mediated high inhibitory tone under resting state. Human and animal studies showed that stress lead to a hyperactivity of amygdala, which was accompanied by the removal of inhibitory control. However, the contribution of hyperactivity of amygdala to stress-induced neuropsychiatric diseases, such as anxiety and mood disorders, is still dubious. In this review, we will summarize stress-induced various structural and functional alterations in amygdala, including the GABA receptors expression, GABAergic transmission and synaptic plasticity. It may provide new insight on the neuropathologic and neurophysiological mechanisms of neuropsychiatric diseases. |
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Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 6% |
Canada | 1 | 6% |
United Kingdom | 1 | 6% |
India | 1 | 6% |
United States | 1 | 6% |
Switzerland | 1 | 6% |
Unknown | 10 | 63% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 13 | 81% |
Scientists | 2 | 13% |
Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 176 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 24 | 14% |
Student > Bachelor | 21 | 12% |
Researcher | 18 | 10% |
Student > Ph. D. Student | 18 | 10% |
Student > Doctoral Student | 10 | 6% |
Other | 25 | 14% |
Unknown | 60 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 35 | 20% |
Agricultural and Biological Sciences | 14 | 8% |
Biochemistry, Genetics and Molecular Biology | 13 | 7% |
Medicine and Dentistry | 12 | 7% |
Psychology | 12 | 7% |
Other | 30 | 17% |
Unknown | 60 | 34% |