The data shown below were collected from the profiles of 73 X users who shared this research output. Click here to find out more about how the information was compiled.
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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Alzheimer's Disease and Type 2 Diabetes: A Critical Assessment of the Shared Pathological Traits
|
|---|---|
| Published in |
Frontiers in Neuroscience, June 2018
|
| DOI | 10.3389/fnins.2018.00383 |
| Pubmed ID | |
| Authors |
Shreyasi Chatterjee, Amritpal Mudher |
| Abstract |
Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM) are two of the most prevalent diseases in the elderly population worldwide. A growing body of epidemiological studies suggest that people with T2DM are at a higher risk of developing AD. Likewise, AD brains are less capable of glucose uptake from the surroundings resembling a condition of brain insulin resistance. Pathologically AD is characterized by extracellular plaques of Aβ and intracellular neurofibrillary tangles of hyperphosphorylated tau. T2DM, on the other hand is a metabolic disorder characterized by hyperglycemia and insulin resistance. In this review we have discussed how Insulin resistance in T2DM directly exacerbates Aβ and tau pathologies and elucidated the pathophysiological traits of synaptic dysfunction, inflammation, and autophagic impairments that are common to both diseases and indirectly impact Aβ and tau functions in the neurons. Elucidation of the underlying pathways that connect these two diseases will be immensely valuable for designing novel drug targets for Alzheimer's disease. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 16% |
| United Kingdom | 5 | 7% |
| Spain | 2 | 3% |
| India | 2 | 3% |
| Finland | 2 | 3% |
| Mexico | 2 | 3% |
| Switzerland | 1 | 1% |
| Canada | 1 | 1% |
| Australia | 1 | 1% |
| Other | 2 | 3% |
| Unknown | 43 | 59% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 51 | 70% |
| Scientists | 14 | 19% |
| Practitioners (doctors, other healthcare professionals) | 8 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 306 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 306 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 45 | 15% |
| Student > Bachelor | 36 | 12% |
| Researcher | 26 | 8% |
| Student > Master | 25 | 8% |
| Other | 11 | 4% |
| Other | 48 | 16% |
| Unknown | 115 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 45 | 15% |
| Neuroscience | 33 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 26 | 8% |
| Medicine and Dentistry | 20 | 7% |
| Agricultural and Biological Sciences | 12 | 4% |
| Other | 45 | 15% |
| Unknown | 125 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 58. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2022.
All research outputs
#772,578
of 26,399,279 outputs
Outputs from Frontiers in Neuroscience
#325
of 11,853 outputs
Outputs of similar age
#16,254
of 345,299 outputs
Outputs of similar age from Frontiers in Neuroscience
#9
of 227 outputs
Altmetric has tracked 26,399,279 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,853 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,299 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 227 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.