Title |
Alzheimer's Disease and Type 2 Diabetes: A Critical Assessment of the Shared Pathological Traits
|
---|---|
Published in |
Frontiers in Neuroscience, June 2018
|
DOI | 10.3389/fnins.2018.00383 |
Pubmed ID | |
Authors |
Shreyasi Chatterjee, Amritpal Mudher |
Abstract |
Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM) are two of the most prevalent diseases in the elderly population worldwide. A growing body of epidemiological studies suggest that people with T2DM are at a higher risk of developing AD. Likewise, AD brains are less capable of glucose uptake from the surroundings resembling a condition of brain insulin resistance. Pathologically AD is characterized by extracellular plaques of Aβ and intracellular neurofibrillary tangles of hyperphosphorylated tau. T2DM, on the other hand is a metabolic disorder characterized by hyperglycemia and insulin resistance. In this review we have discussed how Insulin resistance in T2DM directly exacerbates Aβ and tau pathologies and elucidated the pathophysiological traits of synaptic dysfunction, inflammation, and autophagic impairments that are common to both diseases and indirectly impact Aβ and tau functions in the neurons. Elucidation of the underlying pathways that connect these two diseases will be immensely valuable for designing novel drug targets for Alzheimer's disease. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 12 | 16% |
United Kingdom | 5 | 7% |
Spain | 2 | 3% |
India | 2 | 3% |
Finland | 2 | 3% |
Mexico | 2 | 3% |
Switzerland | 1 | 1% |
Canada | 1 | 1% |
Australia | 1 | 1% |
Other | 2 | 3% |
Unknown | 43 | 59% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 51 | 70% |
Scientists | 14 | 19% |
Practitioners (doctors, other healthcare professionals) | 8 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 306 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 45 | 15% |
Student > Bachelor | 36 | 12% |
Researcher | 26 | 8% |
Student > Master | 25 | 8% |
Other | 11 | 4% |
Other | 48 | 16% |
Unknown | 115 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 45 | 15% |
Neuroscience | 33 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 26 | 8% |
Medicine and Dentistry | 20 | 7% |
Agricultural and Biological Sciences | 12 | 4% |
Other | 45 | 15% |
Unknown | 125 | 41% |