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Attention Score in Context
| Title |
Image-Based Profiling of Synaptic Connectivity in Primary Neuronal Cell Culture
|
|---|---|
| Published in |
Frontiers in Neuroscience, June 2018
|
| DOI | 10.3389/fnins.2018.00389 |
| Pubmed ID | |
| Authors |
Peter Verstraelen, Michiel Van Dyck, Marlies Verschuuren, Nachiket D. Kashikar, Rony Nuydens, Jean-Pierre Timmermans, Winnok H. De Vos |
| Abstract |
Neurological disorders display a broad spectrum of clinical manifestations. Yet, at the cellular level, virtually all these diseases converge into a common phenotype of dysregulated synaptic connectivity. In dementia, synapse dysfunction precedes neurodegeneration and cognitive impairment by several years, making the synapse a crucial entry point for the development of diagnostic and therapeutic strategies. Whereas high-resolution imaging and biochemical fractionations yield detailed insight into the molecular composition of the synapse, standardized assays are required to quickly gauge synaptic connectivity across large populations of cells under a variety of experimental conditions. Such screening capabilities have now become widely accessible with the advent of high-throughput, high-content microscopy. In this review, we discuss how microscopy-based approaches can be used to extract quantitative information about synaptic connectivity in primary neurons with deep coverage. We elaborate on microscopic readouts that may serve as a proxy for morphofunctional connectivity and we critically analyze their merits and limitations. Finally, we allude to the potential of alternative culture paradigms and integrative approaches to enable comprehensive profiling of synaptic connectivity. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 20% |
| United States | 1 | 20% |
| Switzerland | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 213 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 213 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 46 | 22% |
| Researcher | 34 | 16% |
| Student > Master | 21 | 10% |
| Student > Bachelor | 19 | 9% |
| Student > Doctoral Student | 8 | 4% |
| Other | 24 | 11% |
| Unknown | 61 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 53 | 25% |
| Biochemistry, Genetics and Molecular Biology | 32 | 15% |
| Agricultural and Biological Sciences | 24 | 11% |
| Medicine and Dentistry | 8 | 4% |
| Chemistry | 6 | 3% |
| Other | 24 | 11% |
| Unknown | 66 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 December 2022.
All research outputs
#6,376,627
of 25,385,509 outputs
Outputs from Frontiers in Neuroscience
#4,236
of 11,542 outputs
Outputs of similar age
#102,238
of 342,601 outputs
Outputs of similar age from Frontiers in Neuroscience
#95
of 233 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 11,542 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,601 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 233 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.