The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Triglyceride Form of Docosahexaenoic Acid Mediates Neuroprotection in Experimental Parkinsonism
|
|---|---|
| Published in |
Frontiers in Neuroscience, August 2018
|
| DOI | 10.3389/fnins.2018.00604 |
| Pubmed ID | |
| Authors |
Maricel Gómez-Soler, Begoña Cordobilla, Xavier Morató, Víctor Fernández-Dueñas, Joan C. Domingo, Francisco Ciruela |
| Abstract |
Parkinson's disease (PD) is a neurodegenerative disorder of unknown etiology. The main treatment of PD consists of medication with dopamine-based drugs, which palliate the symptoms but may produce adverse effects after chronic administration. Accordingly, there is a need to develop novel neuroprotective therapies. Several studies suggest that omega-3 polyunsaturated fatty acids (n-3 PUFA) might provide protection against brain damage. Here, we studied several experimental models of PD, using striatal neuronal cultures, striatal slices, and mice, to assess the neuroprotective effects of docosahexaenoic acid (DHA), the main n-3 PUFA in the brain, administered in its triglyceride form (TG-DHA). Hence, we determined the beneficial effects of TG-DHA on neural viability following 6-hydroxydopamine (6-OHDA)-induced neurotoxicity, a well-established PD model. We also implemented a novel mouse behavioral test, the beam walking test, to finely assess mouse motor skills following dopaminergic denervation. This test showed potential as a useful behavioral tool to assess novel PD treatments. Our results indicated that TG-DHA-mediated neuroprotection was independent of the net incorporation of PUFA into the striatum, thus suggesting a tight control of brain lipid homeostasis both in normal and pathological conditions. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Norway | 3 | 27% |
| Canada | 1 | 9% |
| Chile | 1 | 9% |
| Unknown | 6 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 46 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 20% |
| Student > Master | 5 | 11% |
| Other | 4 | 9% |
| Student > Ph. D. Student | 4 | 9% |
| Researcher | 3 | 7% |
| Other | 6 | 13% |
| Unknown | 15 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 15% |
| Neuroscience | 6 | 13% |
| Biochemistry, Genetics and Molecular Biology | 5 | 11% |
| Medicine and Dentistry | 4 | 9% |
| Nursing and Health Professions | 1 | 2% |
| Other | 6 | 13% |
| Unknown | 17 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2019.
All research outputs
#6,498,682
of 25,385,509 outputs
Outputs from Frontiers in Neuroscience
#4,312
of 11,542 outputs
Outputs of similar age
#104,962
of 344,178 outputs
Outputs of similar age from Frontiers in Neuroscience
#102
of 241 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 11,542 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,178 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 241 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.