Title |
Tenascins in Retinal and Optic Nerve Neurodegeneration
|
---|---|
Published in |
Frontiers in Integrative Neuroscience, October 2017
|
DOI | 10.3389/fnint.2017.00030 |
Pubmed ID | |
Authors |
Jacqueline Reinhard, Lars Roll, Andreas Faissner |
Abstract |
Tenascins represent key constituents of the extracellular matrix (ECM) with major impact on central nervous system (CNS) development. In this regard, several studies indicate that they play a crucial role in axonal growth and guidance, synaptogenesis and boundary formation. These functions are not only important during development, but also for regeneration under several pathological conditions. Additionally, tenascin-C (Tnc) represents a key modulator of the immune system and inflammatory processes. In the present review article, we focus on the function of Tnc and tenascin-R (Tnr) in the diseased CNS, specifically after retinal and optic nerve damage and degeneration. We summarize the current view on both tenascins in diseases such as glaucoma, retinal ischemia, age-related macular degeneration (AMD) or diabetic retinopathy. In this context, we discuss their expression profile, possible functional relevance, remodeling of the interacting matrisome and tenascin receptors, especially under pathological conditions. |
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