Title |
A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication
|
---|---|
Published in |
Frontiers in Integrative Neuroscience, December 2017
|
DOI | 10.3389/fnint.2017.00033 |
Pubmed ID | |
Authors |
Heleen M. van 't Spijker, Jessica C. F. Kwok |
Abstract |
Perineuronal nets (PNNs) are mesh-like structures, composed of a hierarchical assembly of extracellular matrix molecules in the central nervous system (CNS), ensheathing neurons and regulating plasticity. The mechanism of interactions between PNNs and neurons remain uncharacterized. In this review, we pose the question: how do PNNs regulate communication to and from neurons? We provide an overview of the current knowledge on PNNs with a focus on the cellular interactions. PNNs ensheath a subset of the neuronal population with distinct molecular aspects in different areas of the CNS. PNNs control neuronal communication through molecular interactions involving specific components of the PNNs. This review proposes that the PNNs are an integral part of neurons, crucial for the regulation of plasticity in the CNS. |
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United Kingdom | 3 | 25% |
Spain | 2 | 17% |
United States | 1 | 8% |
Ireland | 1 | 8% |
Switzerland | 1 | 8% |
Unknown | 4 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 9 | 75% |
Scientists | 3 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 178 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 47 | 26% |
Student > Master | 26 | 15% |
Researcher | 20 | 11% |
Student > Bachelor | 15 | 8% |
Student > Doctoral Student | 6 | 3% |
Other | 19 | 11% |
Unknown | 45 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 65 | 37% |
Agricultural and Biological Sciences | 22 | 12% |
Biochemistry, Genetics and Molecular Biology | 14 | 8% |
Medicine and Dentistry | 6 | 3% |
Unspecified | 4 | 2% |
Other | 16 | 9% |
Unknown | 51 | 29% |