Title |
A pivotal role of GSK-3 in synaptic plasticity
|
---|---|
Published in |
Frontiers in Molecular Neuroscience, January 2012
|
DOI | 10.3389/fnmol.2012.00013 |
Pubmed ID | |
Authors |
Clarrisa A. Bradley, Stéphane Peineau, Changiz Taghibiglou, Celine S. Nicolas, Daniel J. Whitcomb, Zuner A. Bortolotto, Bong-Kiun Kaang, Kwangwook Cho, Yu Tian Wang, Graham L. Collingridge |
Abstract |
Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of long-term depression (LTD) that is induced by the synaptic activation of N-methyl-D-aspartate receptors (NMDARs). In the present article we summarize what is currently known concerning the roles of GSK-3 in synaptic plasticity at both glutamatergic and GABAergic synapses. We summarize its role in cognition and speculate on how alterations in the synaptic functioning of GSK-3 may be a major factor in certain neurodegenerative disorders. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Canada | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
United Kingdom | 2 | <1% |
France | 1 | <1% |
Norway | 1 | <1% |
Denmark | 1 | <1% |
Mexico | 1 | <1% |
Unknown | 200 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 44 | 21% |
Researcher | 33 | 16% |
Student > Master | 29 | 14% |
Student > Bachelor | 19 | 9% |
Professor > Associate Professor | 12 | 6% |
Other | 30 | 14% |
Unknown | 41 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 51 | 25% |
Neuroscience | 48 | 23% |
Medicine and Dentistry | 20 | 10% |
Biochemistry, Genetics and Molecular Biology | 18 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
Other | 19 | 9% |
Unknown | 46 | 22% |