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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Investigating neuronal function with optically controllable proteins
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, July 2015
|
| DOI | 10.3389/fnmol.2015.00037 |
| Pubmed ID | |
| Authors |
Xin X. Zhou, Michael Pan, Michael Z. Lin |
| Abstract |
In the nervous system, protein activities are highly regulated in space and time. This regulation allows for fine modulation of neuronal structure and function during development and adaptive responses. For example, neurite extension and synaptogenesis both involve localized and transient activation of cytoskeletal and signaling proteins, allowing changes in microarchitecture to occur rapidly and in a localized manner. To investigate the role of specific protein regulation events in these processes, methods to optically control the activity of specific proteins have been developed. In this review, we focus on how photosensory domains enable optical control over protein activity and have been used in neuroscience applications. These tools have demonstrated versatility in controlling various proteins and thereby cellular functions, and possess enormous potential for future applications in nervous systems. Just as optogenetic control of neuronal firing using opsins has changed how we investigate the function of cellular circuits in vivo, optical control may yet yield another revolution in how we study the circuitry of intracellular signaling in the brain. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 14% |
| Unknown | 6 | 86% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Scientists | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| China | 1 | <1% |
| Unknown | 147 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 36 | 24% |
| Student > Ph. D. Student | 27 | 18% |
| Student > Bachelor | 17 | 11% |
| Professor > Associate Professor | 13 | 9% |
| Student > Doctoral Student | 12 | 8% |
| Other | 26 | 17% |
| Unknown | 18 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 46 | 31% |
| Neuroscience | 33 | 22% |
| Biochemistry, Genetics and Molecular Biology | 19 | 13% |
| Medicine and Dentistry | 8 | 5% |
| Engineering | 7 | 5% |
| Other | 17 | 11% |
| Unknown | 19 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2015.
All research outputs
#8,195,439
of 26,488,660 outputs
Outputs from Frontiers in Molecular Neuroscience
#1,140
of 3,444 outputs
Outputs of similar age
#85,131
of 276,354 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#10
of 31 outputs
Altmetric has tracked 26,488,660 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 3,444 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,354 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.