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Ubiquitin-dependent trafficking and turnover of ionotropic glutamate receptors

Overview of attention for article published in Frontiers in Molecular Neuroscience, October 2015
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Title
Ubiquitin-dependent trafficking and turnover of ionotropic glutamate receptors
Published in
Frontiers in Molecular Neuroscience, October 2015
DOI 10.3389/fnmol.2015.00060
Pubmed ID
Authors

Marisa S. Goo, Samantha L. Scudder, Gentry N. Patrick

Abstract

Changes in synaptic strength underlie the basis of learning and memory and are controlled, in part, by the insertion or removal of AMPA-type glutamate receptors at the postsynaptic membrane of excitatory synapses. Once internalized, these receptors may be recycled back to the plasma membrane by subunit-specific interactions with other proteins or by post-translational modifications such as phosphorylation. Alternatively, these receptors may be targeted for destruction by multiple degradation pathways in the cell. Ubiquitination, another post-translational modification, has recently emerged as a key signal that regulates the recycling and trafficking of glutamate receptors. In this review, we will discuss recent findings on the role of ubiquitination in the trafficking and turnover of ionotropic glutamate receptors and plasticity of excitatory synapses.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 1%
Colombia 1 1%
Unknown 87 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 28%
Researcher 19 21%
Student > Bachelor 10 11%
Professor > Associate Professor 5 6%
Student > Doctoral Student 4 4%
Other 13 15%
Unknown 13 15%
Readers by discipline Count As %
Neuroscience 28 31%
Agricultural and Biological Sciences 19 21%
Biochemistry, Genetics and Molecular Biology 17 19%
Medicine and Dentistry 3 3%
Psychology 2 2%
Other 5 6%
Unknown 15 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2015.
All research outputs
#14,176,999
of 22,830,751 outputs
Outputs from Frontiers in Molecular Neuroscience
#1,505
of 2,878 outputs
Outputs of similar age
#143,956
of 280,050 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#13
of 23 outputs
Altmetric has tracked 22,830,751 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,878 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,050 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.