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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Subcellular Clearance and Accumulation of Huntington Disease Protein: A Mini-Review
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, April 2016
|
| DOI | 10.3389/fnmol.2016.00027 |
| Pubmed ID | |
| Authors |
Ting Zhao, Yan Hong, Xiao-Jiang Li, Shi-Hua Li |
| Abstract |
Huntington's disease (HD) is an autosomal dominant, progressive neurodegenerative disease caused by an expanded polyglutamine (polyQ) tract in the N-terminal region of mutant huntingtin (mHtt). As a result, mHtt forms aggregates that are abundant in the nuclei and processes of neuronal cells. Although the roles of mHtt aggregates are still debated, the formation of aggregates points to deficient clearance of mHtt in brain cells. Since the accumulation of mHtt is a prerequisite for its neurotoxicity, exploring the mechanisms for mHtt accumulation and clearance would advance our understanding of HD pathogenesis and help us develop treatments for HD. We know that the ubiquitin-proteasome system (UPS) and autophagy play important roles in clearing mHtt; however, how mHtt preferentially accumulates in neuronal nuclei and processes remains unclear. Studying the clearance of mHtt in neuronal cells is a challenge because neurons are morphologically and functionally polarized, which means the turnover of mHtt may be distinct in different cellular compartments. In this review, we discuss our current knowledge about the clearance and accumulation of mHtt and strategies examining mHtt clearance and accumulation in different subcellular regions. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 29% |
| Portugal | 1 | 14% |
| Australia | 1 | 14% |
| Switzerland | 1 | 14% |
| Unknown | 2 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Practitioners (doctors, other healthcare professionals) | 1 | 14% |
| Scientists | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | <1% |
| Unknown | 113 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 25% |
| Student > Bachelor | 19 | 17% |
| Student > Master | 17 | 15% |
| Researcher | 12 | 11% |
| Student > Doctoral Student | 7 | 6% |
| Other | 9 | 8% |
| Unknown | 21 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 33 | 29% |
| Agricultural and Biological Sciences | 23 | 20% |
| Neuroscience | 14 | 12% |
| Medicine and Dentistry | 13 | 11% |
| Chemistry | 5 | 4% |
| Other | 7 | 6% |
| Unknown | 19 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2016.
All research outputs
#7,234,904
of 22,865,319 outputs
Outputs from Frontiers in Molecular Neuroscience
#989
of 2,888 outputs
Outputs of similar age
#102,725
of 299,499 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#8
of 26 outputs
Altmetric has tracked 22,865,319 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 2,888 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,499 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.