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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Protective Microglia and Their Regulation in Parkinson’s Disease
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, September 2016
|
| DOI | 10.3389/fnmol.2016.00089 |
| Pubmed ID | |
| Authors |
Weidong Le, Junjiao Wu, Yu Tang |
| Abstract |
Microglia-mediated neuroinflammation is a hallmark of Parkinson's disease (PD). In the brains of patients with PD, microglia have both neurotoxic and neuroprotective effects, depending on their activation state. In this review, we focus on recent research demonstrating the neuroprotective role of microglia in PD. Accumulating evidence indicates that the protective mechanisms of microglia may result from their regulation of transrepression pathways via nuclear receptors, anti-inflammatory responses, neuron-microglia crosstalk, histone modification, and microRNA regulation. All of these mechanisms work together to suppress the production of neurotoxic inflammatory components. However, during the progression of PD, the detrimental effects of inflammation overpower the protective actions of microglia. Therefore, an in-depth exploration of the mechanisms underlying microglial neuroprotection, and a means of promoting the transformation of microglia to the protective phenotype, are urgently needed for the treatment of PD. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 193 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Greece | 1 | <1% |
| Unknown | 191 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 38 | 20% |
| Student > Ph. D. Student | 35 | 18% |
| Student > Bachelor | 27 | 14% |
| Researcher | 16 | 8% |
| Student > Doctoral Student | 7 | 4% |
| Other | 21 | 11% |
| Unknown | 49 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 48 | 25% |
| Biochemistry, Genetics and Molecular Biology | 27 | 14% |
| Agricultural and Biological Sciences | 23 | 12% |
| Medicine and Dentistry | 12 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
| Other | 19 | 10% |
| Unknown | 57 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2021.
All research outputs
#14,271,203
of 22,886,568 outputs
Outputs from Frontiers in Molecular Neuroscience
#1,540
of 2,894 outputs
Outputs of similar age
#182,952
of 320,656 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#18
of 52 outputs
Altmetric has tracked 22,886,568 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,894 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,656 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.