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X Demographics
Mendeley readers
Attention Score in Context
| Title |
ON or OFF?: Modulating the N-Methyl-D-Aspartate Receptor in Major Depression
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, January 2017
|
| DOI | 10.3389/fnmol.2016.00169 |
| Pubmed ID | |
| Authors |
Shi Yu Chan, Edward Matthews, Philip W. J. Burnet |
| Abstract |
Since the discovery that a single dose of ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, had rapid and long-lasting antidepressant effects, there has been increased interest in using NMDAR modulators in the pharmacotherapy of depression. Ketamine's efficacy seems to imply that depression is a disorder of NMDAR hyperfunctionality. However, studies showing that not all NMDAR antagonists are able to act as antidepressants challenge this notion. Furthermore, NMDAR co-agonists have also been gaining attention as possible treatments. Co-agonists such as D-serine and sarcosine have shown efficacy in both pre-clinical models and human trials. This raises the question of how both NMDAR antagonists and agonists are able to have converging behavioral effects. Here we critically review the evidence and proposed therapeutic mechanisms for both NMDAR antagonists and agonists, and collate several theories on how both activation and inhibition of NMDARs appear to have antidepressant effects. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| Unknown | 66 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 16% |
| Student > Bachelor | 10 | 15% |
| Researcher | 9 | 13% |
| Other | 6 | 9% |
| Student > Master | 6 | 9% |
| Other | 10 | 15% |
| Unknown | 15 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 13 | 19% |
| Medicine and Dentistry | 9 | 13% |
| Agricultural and Biological Sciences | 8 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Other | 11 | 16% |
| Unknown | 17 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2017.
All research outputs
#22,751,836
of 25,375,376 outputs
Outputs from Frontiers in Molecular Neuroscience
#2,845
of 3,329 outputs
Outputs of similar age
#371,349
of 434,655 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#70
of 83 outputs
Altmetric has tracked 25,375,376 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,329 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 434,655 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.