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Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)

Overview of attention for article published in Frontiers in Molecular Neuroscience, March 2017
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Title
Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)
Published in
Frontiers in Molecular Neuroscience, March 2017
DOI 10.3389/fnmol.2017.00083
Pubmed ID
Authors

McKenzie L. Ritter, Wei Guo, Jack F. Samuels, Ying Wang, Paul S. Nestadt, Janice Krasnow, Benjamin D. Greenberg, Abby J. Fyer, James T. McCracken, Daniel A. Geller, Dennis L. Murphy, James A. Knowles, Marco A. Grados, Mark A. Riddle, Steven A. Rasmussen, Nicole C. McLaughlin, Erika L. Nurmi, Kathleen D. Askland, Bernadette Cullen, John Piacentini, David L. Pauls, Joseph Bienvenu, Evelyn Stewart, Fernando S. Goes, Brion Maher, Ann E. Pulver, Manuel Mattheisen, Ji Qian, Gerald Nestadt, Yin Yao Shugart

Abstract

Objective: The aim of this study was to identify any potential genetic overlap between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). We hypothesized that since these disorders share a sub-phenotype, they may share common risk alleles. In this manuscript, we report the overlap found between these two disorders. Methods: A meta-analysis was conducted between ADHD and OCD, and polygenic risk scores (PRS) were calculated for both disorders. In addition, a protein-protein analysis was completed in order to examine the interactions between proteins; p-values for the protein-protein interaction analysis was calculated using permutation. Conclusion: None of the single nucleotide polymorphisms (SNPs) reached genome wide significance and there was little evidence of genetic overlap between ADHD and OCD.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 78 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 15%
Student > Ph. D. Student 10 13%
Student > Master 9 12%
Student > Bachelor 8 10%
Other 6 8%
Other 13 17%
Unknown 20 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 16 21%
Psychology 11 14%
Medicine and Dentistry 10 13%
Neuroscience 7 9%
Agricultural and Biological Sciences 4 5%
Other 6 8%
Unknown 24 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2017.
All research outputs
#13,470,448
of 22,961,203 outputs
Outputs from Frontiers in Molecular Neuroscience
#1,287
of 2,900 outputs
Outputs of similar age
#158,039
of 309,217 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#49
of 103 outputs
Altmetric has tracked 22,961,203 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,900 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 309,217 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 103 others from the same source and published within six weeks on either side of this one. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.