Title |
14-3-3 Proteins in Brain Development: Neurogenesis, Neuronal Migration and Neuromorphogenesis
|
---|---|
Published in |
Frontiers in Molecular Neuroscience, October 2017
|
DOI | 10.3389/fnmol.2017.00318 |
Pubmed ID | |
Authors |
Brett Cornell, Kazuhito Toyo-oka |
Abstract |
The 14-3-3 proteins are a family of highly conserved, multifunctional proteins that are highly expressed in the brain during development. Cumulatively, the seven 14-3-3 isoforms make up approximately 1% of total soluble brain protein. Over the last decade, evidence has accumulated implicating the importance of the 14-3-3 protein family in the development of the nervous system, in particular cortical development, and have more recently been recognized as key regulators in a number of neurodevelopmental processes. In this review we will discuss the known roles of each 14-3-3 isoform in the development of the cortex, their relation to human neurodevelopmental disorders, as well as the challenges and questions that are left to be answered. In particular, we focus on the 14-3-3 isoforms and their involvement in the three key stages of cortical development; neurogenesis and differentiation, neuronal migration and neuromorphogenesis and synaptogenesis. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 14% |
Unknown | 6 | 86% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 71% |
Scientists | 1 | 14% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 158 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 23 | 15% |
Student > Bachelor | 21 | 13% |
Student > Master | 19 | 12% |
Researcher | 17 | 11% |
Student > Doctoral Student | 8 | 5% |
Other | 15 | 9% |
Unknown | 55 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 44 | 28% |
Agricultural and Biological Sciences | 24 | 15% |
Neuroscience | 18 | 11% |
Medicine and Dentistry | 6 | 4% |
Chemistry | 4 | 3% |
Other | 4 | 3% |
Unknown | 58 | 37% |