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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, January 2018
|
| DOI | 10.3389/fnmol.2017.00436 |
| Pubmed ID | |
| Authors |
Marc S. Stieglitz, Stefanie Fenske, Verena Hammelmann, Elvir Becirovic, Verena Schöttle, James E. Delorme, Martha Schöll-Weidinger, Robert Mader, Jan Deussing, David P. Wolfer, Mathias W. Seeliger, Urs Albrecht, Carsten T. Wotjak, Martin Biel, Stylianos Michalakis, Christian Wahl-Schott |
| Abstract |
Hyperpolarization-activated cyclic nucleotide-gated channels (HCNs) in the nervous system are implicated in a variety of neuronal functions including learning and memory, regulation of vigilance states and pain. Dysfunctions or genetic loss of these channels have been shown to cause human diseases such as epilepsy, depression, schizophrenia, and Parkinson's disease. The physiological functions of HCN1 and HCN2 channels in the nervous system have been analyzed using genetic knockout mouse models. By contrast, there are no such genetic studies for HCN3 channels so far. Here, we use a HCN3-deficient (HCN3-/-) mouse line, which has been previously generated in our group to examine the expression and function of this channel in the CNS. Specifically, we investigate the role of HCN3 channels for the regulation of circadian rhythm and for the determination of behavior. Contrary to previous suggestions we find that HCN3-/- mice show normal visual, photic, and non-photic circadian function. In addition, HCN3-/- mice are impaired in processing contextual information, which is characterized by attenuated long-term extinction of contextual fear and increased fear to a neutral context upon repeated exposure. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| Nigeria | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 49 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 20% |
| Researcher | 8 | 16% |
| Student > Master | 4 | 8% |
| Student > Bachelor | 3 | 6% |
| Student > Doctoral Student | 2 | 4% |
| Other | 6 | 12% |
| Unknown | 16 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 9 | 18% |
| Medicine and Dentistry | 7 | 14% |
| Biochemistry, Genetics and Molecular Biology | 4 | 8% |
| Psychology | 4 | 8% |
| Agricultural and Biological Sciences | 2 | 4% |
| Other | 5 | 10% |
| Unknown | 18 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2018.
All research outputs
#13,577,300
of 23,015,156 outputs
Outputs from Frontiers in Molecular Neuroscience
#1,327
of 2,912 outputs
Outputs of similar age
#220,816
of 443,107 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#49
of 118 outputs
Altmetric has tracked 23,015,156 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,912 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 443,107 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 118 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.