Title |
Brain Lateralization in Mice Is Associated with Zinc Signaling and Altered in Prenatal Zinc Deficient Mice That Display Features of Autism Spectrum Disorder
|
---|---|
Published in |
Frontiers in Molecular Neuroscience, January 2018
|
DOI | 10.3389/fnmol.2017.00450 |
Pubmed ID | |
Authors |
Stefanie Grabrucker, Jasmin C. Haderspeck, Ann Katrin Sauer, Nadine Kittelberger, Harun Asoglu, Alireza Abaei, Volker Rasche, Michael Schön, Tobias M. Boeckers, Andreas M. Grabrucker |
Abstract |
A number of studies have reported changes in the hemispheric dominance in autism spectrum disorder (ASD) patients on functional, biochemical, and morphological level. Since asymmetry of the brain is also found in many vertebrates, we analyzed whether prenatal zinc deficient (PZD) mice, a mouse model with ASD like behavior, show alterations regarding brain lateralization on molecular and behavioral level. Our results show that hemisphere-specific expression of marker genes is abolished in PZD mice on mRNA and protein level. Using magnetic resonance imaging, we found an increased striatal volume in PZD mice with no change in total brain volume. Moreover, behavioral patterns associated with striatal lateralization are altered and the lateralized expression of dopamine receptor 1 (DR1) in the striatum of PZD mice was changed. We conclude that zinc signaling during brain development has a critical role in the establishment of brain lateralization in mice. |
![](/details/assets/components/timeline_promo/Chart-small-64d94c38d69f046c3ba53a2d94fbe59735ff15de00151846a6c730aad58629ed.png)
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 9% |
Ireland | 1 | 9% |
Australia | 1 | 9% |
United States | 1 | 9% |
Switzerland | 1 | 9% |
Comoros | 1 | 9% |
Unknown | 5 | 45% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 64% |
Scientists | 4 | 36% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 56 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 21% |
Student > Bachelor | 10 | 18% |
Researcher | 7 | 13% |
Student > Doctoral Student | 4 | 7% |
Student > Master | 4 | 7% |
Other | 6 | 11% |
Unknown | 13 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 13 | 23% |
Biochemistry, Genetics and Molecular Biology | 7 | 13% |
Medicine and Dentistry | 5 | 9% |
Social Sciences | 3 | 5% |
Agricultural and Biological Sciences | 3 | 5% |
Other | 11 | 20% |
Unknown | 14 | 25% |