The data shown below were collected from the profiles of 64 X users who shared this research output. Click here to find out more about how the information was compiled.
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Ketogenic Diet Improves Brain Ischemic Tolerance and Inhibits NLRP3 Inflammasome Activation by Preventing Drp1-Mediated Mitochondrial Fission and Endoplasmic Reticulum Stress
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, March 2018
|
| DOI | 10.3389/fnmol.2018.00086 |
| Pubmed ID | |
| Authors |
Min Guo, Xun Wang, Yanxin Zhao, Qi Yang, Hongyan Ding, Qiang Dong, Xingdong Chen, Mei Cui |
| Abstract |
Background: Neuroprotective effects of ketogenic diets (KD) have been reported in stroke models, and nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome has also been implicated in the pathogenesis of stroke. This study aimed to investigate the effects of KD on NLRP3 inflammasome and explore the potential molecular mechanisms. Methods: In in vivo study, mice were fed with KD for 3 weeks and then subjected to middle cerebral artery occlusion/reperfusion (MCAO/R)-injury. In in vitro study, SH-SY-5Y cells were treated with β-hydroxybutyrate (BHB) followed by oxygen-glucose deprivation/reoxygenation (OGD/R). NLRP3 inflammasome activation and related regulatory mechanisms were evaluated. Results: Mice fed with KD had increased tolerance to MCAO/R. KD inhibited endoplasmic reticulum (ER) stress and suppressed TXNIP/NLRP3 inflammasome activation in the brain. The in vitro study showed BHB (10 mM) prevented the mitochondrial translocation of dynamin-related protein 1 (Drp1) to inhibit mitochondrial fission. Furthermore, BHB decreased reactive oxygen species (ROS) generation, inhibited ROS-NLRP3 pathway in OGD/R-treated cells, and suppressed ER stress-induced NLRP3 inflammasome activation. Conclusions: KD may suppress ER stress and protect mitochondrial integrity by suppressing the mitochondrial translocation of Drp1 to inhibit NLRP3 inflammasome activation, thus exerting neuroprotective effects. Our findings provide evidence for the potential application of KD in the prevention of ischemic stroke. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 20 | 31% |
| Canada | 3 | 5% |
| United Kingdom | 3 | 5% |
| Japan | 1 | 2% |
| Sweden | 1 | 2% |
| Philippines | 1 | 2% |
| Unknown | 35 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 47 | 73% |
| Practitioners (doctors, other healthcare professionals) | 12 | 19% |
| Scientists | 4 | 6% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 84 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 13 | 15% |
| Student > Ph. D. Student | 11 | 13% |
| Researcher | 9 | 11% |
| Student > Doctoral Student | 8 | 10% |
| Student > Bachelor | 5 | 6% |
| Other | 9 | 11% |
| Unknown | 29 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 19 | 23% |
| Agricultural and Biological Sciences | 10 | 12% |
| Biochemistry, Genetics and Molecular Biology | 7 | 8% |
| Medicine and Dentistry | 7 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
| Other | 8 | 10% |
| Unknown | 28 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 55. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2023.
All research outputs
#820,267
of 26,536,755 outputs
Outputs from Frontiers in Molecular Neuroscience
#52
of 3,448 outputs
Outputs of similar age
#17,780
of 352,230 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#3
of 126 outputs
Altmetric has tracked 26,536,755 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,448 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,230 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 126 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.