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X Demographics
Mendeley readers
Attention Score in Context
| Title |
New Insights Into Interactions of Presynaptic Calcium Channel Subtypes and SNARE Proteins in Neurotransmitter Release
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, July 2018
|
| DOI | 10.3389/fnmol.2018.00213 |
| Pubmed ID | |
| Authors |
Rongfang He, Juan Zhang, Yiyan Yu, Laluo Jizi, Weizhong Wang, Miaoling Li |
| Abstract |
Action potential (AP) induces presynaptic membrane depolarization and subsequent opening of Ca2+ channels, and then triggers neurotransmitter release at the active zone of presynaptic terminal. Presynaptic Ca2+ channels and SNARE proteins (SNAREs) interactions form a large signal transfer complex, which are core components for exocytosis. Ca2+ channels serve to regulate the activity of Ca2+ channels through direct binding and indirect activation of active zone proteins and SNAREs. The activation of Ca2+ channels promotes synaptic vesicle recruitment, docking, priming, fusion and neurotransmission release. Intracellular calcium increase is a key step for the initiation of vesicle fusion. Various voltage-gated calcium channel (VGCC) subtypes exert different physiological functions. Until now, it has not been clear how different subtypes of calcium channels integrally regulate the release of neurotransmitters within 200 μs of the AP arriving at the active zone of synaptic terminal. In this mini review, we provide a brief overview of the structure and physiological function of Ca2+ channel subtypes, interactions of Ca2+ channels and SNAREs in neurotransmitter release, and dynamic fine-tune Ca2+ channel activities by G proteins (Gβγ), multiple protein kinases and Ca2+ sensor (CaS) proteins. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 91 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 20 | 22% |
| Student > Ph. D. Student | 14 | 15% |
| Researcher | 8 | 9% |
| Student > Master | 7 | 8% |
| Student > Doctoral Student | 4 | 4% |
| Other | 10 | 11% |
| Unknown | 28 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 19 | 21% |
| Biochemistry, Genetics and Molecular Biology | 19 | 21% |
| Agricultural and Biological Sciences | 12 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 7% |
| Medicine and Dentistry | 3 | 3% |
| Other | 2 | 2% |
| Unknown | 30 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2018.
All research outputs
#14,421,028
of 23,096,849 outputs
Outputs from Frontiers in Molecular Neuroscience
#1,555
of 2,930 outputs
Outputs of similar age
#185,231
of 326,758 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#55
of 119 outputs
Altmetric has tracked 23,096,849 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,930 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 326,758 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 119 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.