You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Inflammasome Proteins in Serum and Serum-Derived Extracellular Vesicles as Biomarkers of Stroke
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, September 2018
|
| DOI | 10.3389/fnmol.2018.00309 |
| Pubmed ID | |
| Authors |
Nadine Kerr, Marta García-Contreras, Sam Abbassi, Nancy H. Mejias, Brandon R. Desousa, Camillo Ricordi, W. Dalton Dietrich, Robert W. Keane, Juan Pablo de Rivero Vaccari |
| Abstract |
The inflammasome is a key contributor to the inflammatory innate immune response after stroke. We have previously shown that inflammasome proteins are released in extracellular vesicles (EV) after brain and spinal cord injury. In addition, we have shown that inflammasome proteins offer great promise as biomarkers of central nervous system (CNS) injury following brain trauma. In the present study, we used a Simple Plex Assay (Protein Simple), a novel multi-analyte automated microfluidic immunoassay platform, to analyze serum and serum-derived EV samples from stroke patients and control subjects for inflammasome protein levels of caspase-1, apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC), Interleukins (IL)-1β, and (IL)-18. Receiver operator characteristic (ROC) curves with associated confidence intervals obtained from the analysis of serum samples revealed that the area under the curve (AUC) for ASC was 0.99 with a confidence interval between 0.9914 and 1.004, whereas the AUC for caspase-1, IL-1β, and IL-18 were 0.75, 0.61, and 0.67, respectively. Thus, these data indicate that ASC is a potential biomarker of stroke and highlight the role of the inflammasome in the inflammatory response after brain ischemia. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 18% |
| Sweden | 1 | 9% |
| Australia | 1 | 9% |
| United States | 1 | 9% |
| Switzerland | 1 | 9% |
| Unknown | 5 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 55% |
| Scientists | 2 | 18% |
| Practitioners (doctors, other healthcare professionals) | 2 | 18% |
| Science communicators (journalists, bloggers, editors) | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 57 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 12% |
| Researcher | 7 | 12% |
| Student > Bachelor | 7 | 12% |
| Student > Master | 5 | 9% |
| Student > Postgraduate | 4 | 7% |
| Other | 9 | 16% |
| Unknown | 18 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 18% |
| Medicine and Dentistry | 7 | 12% |
| Neuroscience | 6 | 11% |
| Immunology and Microbiology | 5 | 9% |
| Agricultural and Biological Sciences | 3 | 5% |
| Other | 6 | 11% |
| Unknown | 20 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2019.
All research outputs
#5,765,383
of 23,846,647 outputs
Outputs from Frontiers in Molecular Neuroscience
#771
of 3,094 outputs
Outputs of similar age
#96,783
of 338,241 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#44
of 133 outputs
Altmetric has tracked 23,846,647 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,094 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 338,241 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 133 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.