↓ Skip to main content

The Regulation of Axon Diameter: From Axonal Circumferential Contractility to Activity-Dependent Axon Swelling

Overview of attention for article published in Frontiers in Molecular Neuroscience, September 2018
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

twitter
22 X users
video
1 YouTube creator

Citations

dimensions_citation
56 Dimensions

Readers on

mendeley
132 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
The Regulation of Axon Diameter: From Axonal Circumferential Contractility to Activity-Dependent Axon Swelling
Published in
Frontiers in Molecular Neuroscience, September 2018
DOI 10.3389/fnmol.2018.00319
Pubmed ID
Authors

Ana Rita Costa, Rita Pinto-Costa, Sara Castro Sousa, Mónica Mendes Sousa

Abstract

In the adult nervous system axon caliber varies widely amongst different tracts. When considering a given axon, its diameter can further fluctuate in space and time, according to processes including the distribution of organelles and activity-dependent mechanisms. In addition, evidence is emerging supporting that in axons circumferential tension/contractility is present. Axonal diameter is generically regarded as being regulated by neurofilaments. When neurofilaments are absent or low, microtubule-dependent mechanisms can also contribute to the regulation of axon caliber. Despite this knowledge, the fine-tune mechanisms controlling diameter and circumferential tension throughout the lifetime of an axon, remain largely elusive. Recent data supports the role of the actin-spectrin-based membrane periodic skeleton and of non-muscle myosin II in the control of axon diameter. However, the cytoskeletal arrangement that underlies circumferential axonal contraction and expansion is still to be discovered. Here, we discuss in a critical viewpoint the existing knowledge on the regulation of axon diameter, with a specific focus on the possible role played by the axonal actin cytoskeleton.

X Demographics

X Demographics

The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 132 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 29 22%
Researcher 18 14%
Student > Bachelor 15 11%
Student > Doctoral Student 12 9%
Student > Master 12 9%
Other 16 12%
Unknown 30 23%
Readers by discipline Count As %
Neuroscience 35 27%
Biochemistry, Genetics and Molecular Biology 17 13%
Agricultural and Biological Sciences 13 10%
Medicine and Dentistry 5 4%
Engineering 5 4%
Other 17 13%
Unknown 40 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2022.
All research outputs
#2,525,789
of 24,166,768 outputs
Outputs from Frontiers in Molecular Neuroscience
#255
of 3,152 outputs
Outputs of similar age
#51,706
of 338,955 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#16
of 133 outputs
Altmetric has tracked 24,166,768 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,152 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 338,955 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 133 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.