You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Targeting NLRP3 Inflammasome in the Treatment of CNS Diseases
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, September 2018
|
| DOI | 10.3389/fnmol.2018.00320 |
| Pubmed ID | |
| Authors |
Bo-Zong Shao, Qi Cao, Chong Liu |
| Abstract |
Central nervous system (CNS) is one of the largest killers of people's health all over the world. The overactivation of the immune and inflammatory responses is considered as an important factor, contributing to the pathogenesis and progression of CNS disorders. Among all kinds of immune and inflammatory reaction, the inflammasome, a complex of proteins, has been drawn increasingly attention to by researchers. The initiation and activation of the inflammasome is involved in the onset of various kinds of diseases. The NLRP3 inflammasome, the most studied member of the inflammasome, is closely associated with many kinds of CNS disorders. Here in this review, the roles of the NLRP3 inflammasome in the pathogenesis and progression of several well-known CNS diseases would be discussed, including cerebrovascular diseases, neurodegenerative diseases, multiple sclerosis, depression as well as other CNS disorders. In addition, several therapeutic strategies targeting on the NLRP3 inflammasome for the treatment of CNS disorders would be described in this review. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 108 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 13% |
| Researcher | 13 | 12% |
| Student > Bachelor | 13 | 12% |
| Student > Master | 12 | 11% |
| Other | 6 | 6% |
| Other | 11 | 10% |
| Unknown | 39 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 16 | 15% |
| Biochemistry, Genetics and Molecular Biology | 12 | 11% |
| Agricultural and Biological Sciences | 10 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 7% |
| Medicine and Dentistry | 6 | 6% |
| Other | 12 | 11% |
| Unknown | 44 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2019.
All research outputs
#13,626,495
of 23,103,436 outputs
Outputs from Frontiers in Molecular Neuroscience
#1,328
of 2,931 outputs
Outputs of similar age
#171,169
of 335,391 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#69
of 133 outputs
Altmetric has tracked 23,103,436 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,931 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,391 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 133 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.