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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Enhanced synaptic transmission at the squid giant synapse by artificial seawater based on physically modified saline
|
|---|---|
| Published in |
Frontiers in Synaptic Neuroscience, January 2014
|
| DOI | 10.3389/fnsyn.2014.00002 |
| Pubmed ID | |
| Authors |
Soonwook Choi, Eunah Yu, Guilherme Rabello, Suelen Merlo, Ajmal Zemmar, Kerry D. Walton, Herman Moreno, Jorge E. Moreira, Mutsuyuki Sugimori, Rodolfo R. Llinás |
| Abstract |
Superfusion of the squid giant synapse with artificial seawater (ASW) based on isotonic saline containing oxygen nanobubbles (RNS60 ASW) generates an enhancement of synaptic transmission. This was determined by examining the postsynaptic response to single and repetitive presynaptic spike activation, spontaneous transmitter release, and presynaptic voltage clamp studies. In the presence of RNS60 ASW single presynaptic stimulation elicited larger postsynaptic potentials (PSP) and more robust recovery from high frequency stimulation than in control ASW. Analysis of postsynaptic noise revealed an increase in spontaneous transmitter release with modified noise kinetics in RNS60 ASW. Presynaptic voltage clamp demonstrated an increased EPSP, without an increase in presynaptic ICa(++) amplitude during RNS60 ASW superfusion. Synaptic release enhancement reached stable maxima within 5-10 min of RNS60 ASW superfusion and was maintained for the entire recording time, up to 1 h. Electronmicroscopic morphometry indicated a decrease in synaptic vesicle density and the number at active zones with an increase in the number of clathrin-coated vesicles (CCV) and large endosome-like vesicles near junctional sites. Block of mitochondrial ATP synthesis by presynaptic injection of oligomycin reduced spontaneous release and prevented the synaptic noise increase seen in RNS60 ASW. After ATP block the number of vesicles at the active zone and CCV was reduced, with an increase in large vesicles. The possibility that RNS60 ASW acts by increasing mitochondrial ATP synthesis was tested by direct determination of ATP levels in both presynaptic and postsynaptic structures. This was implemented using luciferin/luciferase photon emission, which demonstrated a marked increase in ATP synthesis following RNS60 administration. It is concluded that RNS60 positively modulates synaptic transmission by up-regulating ATP synthesis, thus leading to synaptic transmission enhancement. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 2 | 13% |
| Mexico | 1 | 7% |
| United States | 1 | 7% |
| Unknown | 11 | 73% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 87% |
| Practitioners (doctors, other healthcare professionals) | 1 | 7% |
| Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 20% |
| Researcher | 5 | 17% |
| Student > Master | 3 | 10% |
| Student > Doctoral Student | 2 | 7% |
| Other | 2 | 7% |
| Other | 8 | 27% |
| Unknown | 4 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 5 | 17% |
| Engineering | 3 | 10% |
| Immunology and Microbiology | 3 | 10% |
| Arts and Humanities | 2 | 7% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Other | 8 | 27% |
| Unknown | 7 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 December 2022.
All research outputs
#1,870,509
of 26,254,370 outputs
Outputs from Frontiers in Synaptic Neuroscience
#19
of 447 outputs
Outputs of similar age
#20,164
of 322,484 outputs
Outputs of similar age from Frontiers in Synaptic Neuroscience
#1
of 2 outputs
Altmetric has tracked 26,254,370 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 447 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,484 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them