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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genetic targeting of NRXN2 in mice unveils role in excitatory cortical synapse function and social behaviors
|
|---|---|
| Published in |
Frontiers in Synaptic Neuroscience, February 2015
|
| DOI | 10.3389/fnsyn.2015.00003 |
| Pubmed ID | |
| Authors |
Gesche Born, Hannah M. Grayton, Hanna Langhorst, Irina Dudanova, Astrid Rohlmann, Benjamin W. Woodward, David A. Collier, Cathy Fernandes, Markus Missler |
| Abstract |
Human genetics has identified rare copy number variations and deleterious mutations for all neurexin genes (NRXN1-3) in patients with neurodevelopmental diseases, and electrophysiological recordings in animal brains have shown that Nrxns are important for synaptic transmission. While several mouse models for Nrxn1α inactivation have previously been studied for behavioral changes, very little information is available for other variants. Here, we validate that mice lacking Nrxn2α exhibit behavioral abnormalities, characterized by social interaction deficits and increased anxiety-like behavior, which partially overlap, partially differ from Nrxn1α mutant behaviors. Using patch-clamp recordings in Nrxn2α knockout brains, we observe reduced spontaneous transmitter release at excitatory synapses in the neocortex. We also analyse at this cellular level a novel NRXN2 mouse model that carries a combined deletion of Nrxn2α and Nrxn2β. Electrophysiological analysis of this Nrxn2-mutant mouse shows surprisingly similar defects of excitatory release to Nrxn2α, indicating that the β-variant of Nrxn2 has no strong function in basic transmission at these synapses. Inhibitory transmission as well as synapse densities and ultrastructure remain unchanged in the neocortex of both models. Furthermore, at Nrxn2α and Nrxn2-mutant excitatory synapses we find an altered facilitation and N-methyl-D-aspartate receptor (NMDAR) function because NMDAR-dependent decay time and NMDAR-mediated responses are reduced. As Nrxn can indirectly be linked to NMDAR via neuroligin and PSD-95, the trans-synaptic nature of this complex may help to explain occurrence of presynaptic and postsynaptic effects. Since excitatory/inhibitory imbalances and impairment of NMDAR function are alledged to have a role in autism and schizophrenia, our results support the idea of a related pathomechanism in these disorders. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Israel | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 104 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 24% |
| Researcher | 21 | 20% |
| Student > Master | 13 | 12% |
| Student > Bachelor | 11 | 10% |
| Student > Doctoral Student | 4 | 4% |
| Other | 14 | 13% |
| Unknown | 18 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 27 | 25% |
| Neuroscience | 25 | 23% |
| Biochemistry, Genetics and Molecular Biology | 15 | 14% |
| Medicine and Dentistry | 7 | 7% |
| Psychology | 6 | 6% |
| Other | 4 | 4% |
| Unknown | 23 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2015.
All research outputs
#14,804,483
of 22,794,367 outputs
Outputs from Frontiers in Synaptic Neuroscience
#256
of 408 outputs
Outputs of similar age
#142,631
of 255,123 outputs
Outputs of similar age from Frontiers in Synaptic Neuroscience
#3
of 7 outputs
Altmetric has tracked 22,794,367 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 408 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,123 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.