Title |
A Focus on Reward Prediction and the Lateral Habenula: Functional Alterations and the Behavioral Outcomes Induced by Drugs of Abuse
|
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Published in |
Frontiers in Synaptic Neuroscience, May 2018
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DOI | 10.3389/fnsyn.2018.00012 |
Pubmed ID | |
Authors |
Nicholas M. Graziane, Peter A. Neumann, Yan Dong |
Abstract |
The lateral habenula (LHb) regulates reward learning and controls the updating of reward-related information. Drugs of abuse have the capacity to hijack the cellular and neurocircuit mechanisms mediating reward learning, forming non-adaptable, compulsive behaviors geared toward obtaining illicit substances. Here, we discuss current findings demonstrating how drugs of abuse alter intrinsic and synaptic LHb neuronal function. Additionally, we discuss evidence for how drug-induced LHb alterations may affect the ability to predict reward, potentially facilitating an addiction-like state. Altogether, we combine ex vivo and in vivo results for an overview of how drugs of abuse alter LHb function and how these functional alterations affect the ability to learn and update behavioral responses to hedonic external stimuli. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 23% |
Student > Bachelor | 4 | 13% |
Professor | 4 | 13% |
Researcher | 3 | 10% |
Student > Master | 2 | 6% |
Other | 1 | 3% |
Unknown | 10 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 13 | 42% |
Agricultural and Biological Sciences | 3 | 10% |
Medicine and Dentistry | 2 | 6% |
Psychology | 2 | 6% |
Nursing and Health Professions | 1 | 3% |
Other | 2 | 6% |
Unknown | 8 | 26% |