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Glutathione S-Transferases in Pediatric Cancer

Overview of attention for article published in Frontiers in oncology, January 2011
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Title
Glutathione S-Transferases in Pediatric Cancer
Published in
Frontiers in oncology, January 2011
DOI 10.3389/fonc.2011.00039
Pubmed ID
Authors

Wen Luo, Michelle Kinsey, Joshua D. Schiffman, Stephen L. Lessnick

Abstract

The glutathione S-transferases (GSTs) are a family of ubiquitously expressed polymorphic enzymes important for detoxifying endogenous and exogenous compounds. In addition to their classic activity of detoxification by conjugation of compounds with glutathione, many other functions are now found to be associated with GSTs. The associations between GST polymorphisms/functions and human disease susceptibility or treatment outcome, mostly in adults, have been extensively studied and reviewed. This mini review focuses on studies related to GST epidemiology and functions related to pediatric cancer. Opportunities to exploit GST in pediatric cancer therapy are also discussed.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 3%
Unknown 31 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 25%
Student > Master 6 19%
Professor 2 6%
Student > Bachelor 2 6%
Unspecified 2 6%
Other 6 19%
Unknown 6 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 34%
Agricultural and Biological Sciences 6 19%
Medicine and Dentistry 3 9%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Unspecified 1 3%
Other 2 6%
Unknown 8 25%