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K63-Linked Ubiquitination in Kinase Activation and Cancer

Overview of attention for article published in Frontiers in oncology, January 2012
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

Mentioned by

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2 X users

Citations

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89 Dimensions

Readers on

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134 Mendeley
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Title
K63-Linked Ubiquitination in Kinase Activation and Cancer
Published in
Frontiers in oncology, January 2012
DOI 10.3389/fonc.2012.00005
Pubmed ID
Authors

Guocan Wang, Yuan Gao, Liren Li, Guoxiang Jin, Zhen Cai, Jui-I Chao, Hui-Kuan Lin

Abstract

Ubiquitination has been demonstrated to play a pivotal role in multiple biological functions, which include cell growth, proliferation, apoptosis, DNA damage response, innate immune response, and neuronal degeneration. Although the role of ubiquitination in targeting proteins for proteasome-dependent degradation have been extensively studied and well-characterized, the critical non-proteolytic functions of ubiquitination, such as protein trafficking and kinase activation, involved in cell survival and cancer development, just start to emerge, In this review, we will summarize recent progresses in elucidating the non-proteolytic function of ubiquitination signaling in protein kinase activation and its implications in human cancers. The advancement in the understanding of the novel functions of ubiquitination in signal transduction pathways downstream of growth factor receptors may provide novel paradigms for the treatment of human cancers.

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Unknown 133 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 29 22%
Researcher 22 16%
Student > Master 16 12%
Student > Bachelor 14 10%
Student > Postgraduate 7 5%
Other 16 12%
Unknown 30 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 49 37%
Agricultural and Biological Sciences 22 16%
Medicine and Dentistry 8 6%
Chemistry 7 5%
Immunology and Microbiology 5 4%
Other 11 8%
Unknown 32 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2014.
All research outputs
#17,853,992
of 26,150,873 outputs
Outputs from Frontiers in oncology
#8,251
of 22,908 outputs
Outputs of similar age
#176,314
of 253,332 outputs
Outputs of similar age from Frontiers in oncology
#71
of 162 outputs
Altmetric has tracked 26,150,873 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 22,908 research outputs from this source. They receive a mean Attention Score of 2.9. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 253,332 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 162 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.