Title |
ALK Signaling and Target Therapy in Anaplastic Large Cell Lymphoma
|
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Published in |
Frontiers in oncology, January 2012
|
DOI | 10.3389/fonc.2012.00041 |
Pubmed ID | |
Authors |
Fabrizio Tabbó, Antonella Barreca, Roberto Piva, Giorgio Inghirami, The European T-Cell Lymphoma Study Group |
Abstract |
The discovery by Morris et al. (1994) of the genes contributing to the t(2;5)(p23;q35) translocation has laid the foundation for a molecular based recognition of anaplastic large cell lymphoma and highlighted the need for a further stratification of T-cell neoplasia. Likewise the detection of anaplastic lymphoma kinase (ALK) genetic lesions among many human cancers has defined unique subsets of cancer patients, providing new opportunities for innovative therapeutic interventions. The objective of this review is to appraise the molecular mechanisms driving ALK-mediated transformation, and to maintain the neoplastic phenotype. The understanding of these events will allow the design and implementation of novel tailored strategies for a well-defined subset of cancer patients. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 2% |
Unknown | 58 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 22% |
Student > Ph. D. Student | 10 | 17% |
Student > Bachelor | 5 | 8% |
Student > Doctoral Student | 5 | 8% |
Student > Postgraduate | 5 | 8% |
Other | 11 | 19% |
Unknown | 10 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 16 | 27% |
Medicine and Dentistry | 12 | 20% |
Agricultural and Biological Sciences | 10 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
Chemistry | 3 | 5% |
Other | 4 | 7% |
Unknown | 10 | 17% |