Title |
A Model of Dendritic Cell Therapy for Melanoma
|
---|---|
Published in |
Frontiers in oncology, January 2013
|
DOI | 10.3389/fonc.2013.00056 |
Pubmed ID | |
Authors |
Lisette DePillis, Angela Gallegos, Ami Radunskaya |
Abstract |
Dendritic cells are a promising immunotherapy tool for boosting an individual's antigen-specific immune response to cancer. We develop a mathematical model using differential and delay-differential equations to describe the interactions between dendritic cells, effector-immune cells, and tumor cells. We account for the trafficking of immune cells between lymph, blood, and tumor compartments. Our model reflects experimental results both for dendritic cell trafficking and for immune suppression of tumor growth in mice. In addition, in silico experiments suggest more effective immunotherapy treatment protocols can be achieved by modifying dose location and schedule. A sensitivity analysis of the model reveals which patient-specific parameters have the greatest impact on treatment efficacy. |
X Demographics
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Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 69 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 20% |
Student > Bachelor | 12 | 17% |
Researcher | 9 | 13% |
Student > Doctoral Student | 7 | 10% |
Other | 6 | 9% |
Other | 12 | 17% |
Unknown | 9 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 13 | 19% |
Mathematics | 9 | 13% |
Biochemistry, Genetics and Molecular Biology | 5 | 7% |
Medicine and Dentistry | 5 | 7% |
Engineering | 5 | 7% |
Other | 19 | 28% |
Unknown | 13 | 19% |