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Cancer Karyotypes: Survival of the Fittest

Overview of attention for article published in Frontiers in oncology, January 2013
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2 X users

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135 Mendeley
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Title
Cancer Karyotypes: Survival of the Fittest
Published in
Frontiers in oncology, January 2013
DOI 10.3389/fonc.2013.00148
Pubmed ID
Authors

Joshua M. Nicholson, Daniela Cimini

Abstract

Cancer cells are typically characterized by complex karyotypes including both structural and numerical changes, with aneuploidy being a ubiquitous feature. It is becoming increasingly evident that aneuploidy per se can cause chromosome mis-segregation, which explains the higher rates of chromosome gain/loss observed in aneuploid cancer cells compared to normal diploid cells, a phenotype termed chromosomal instability (CIN). CIN can be caused by various mechanisms and results in extensive karyotypic heterogeneity within a cancer cell population. However, despite such karyotypic heterogeneity, cancer cells also display predominant karyotypic patterns. In this review we discuss the mechanisms of CIN, with particular emphasis on the role of aneuploidy on CIN. Further, we discuss the potential functional role of karyotypic patterns in cancer.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 135 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 2 1%
Denmark 1 <1%
Germany 1 <1%
Unknown 131 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 20%
Student > Bachelor 19 14%
Student > Master 18 13%
Researcher 17 13%
Student > Doctoral Student 10 7%
Other 16 12%
Unknown 28 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 49 36%
Agricultural and Biological Sciences 34 25%
Medicine and Dentistry 8 6%
Immunology and Microbiology 2 1%
Veterinary Science and Veterinary Medicine 2 1%
Other 12 9%
Unknown 28 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2014.
All research outputs
#20,294,025
of 25,806,080 outputs
Outputs from Frontiers in oncology
#9,505
of 22,805 outputs
Outputs of similar age
#223,801
of 291,290 outputs
Outputs of similar age from Frontiers in oncology
#140
of 328 outputs
Altmetric has tracked 25,806,080 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 22,805 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,290 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 328 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.