Title |
Granulocyte Colony-Stimulating Factor Receptor Mutations in Myeloid Malignancy
|
---|---|
Published in |
Frontiers in oncology, May 2014
|
DOI | 10.3389/fonc.2014.00093 |
Pubmed ID | |
Authors |
Clifford Liongue, Alister Curtis Ward |
Abstract |
Granulocyte colony-stimulating factor is a cytokine able to stimulate both myelopoiesis and hematopoietic stem cell mobilization, which has seen it used extensively in the clinic to aid hematopoietic recovery. It acts specifically via the homodimeric granulocyte colony-stimulating factor receptor (G-CSFR), which is principally expressed on the surface of myeloid and hematopoietic progenitor cells. A number of pathogenic mutations have now been identified in CSF3R, the gene encoding G-CSFR. These fall into distinct classes, each of which is associated with a particular spectrum of myeloid disorders, including malignancy. This review details the various CSF3R mutations, their mechanisms of action, and contribution to disease, as well as discussing the clinical implications of such mutations. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 16% |
Researcher | 7 | 16% |
Student > Bachelor | 7 | 16% |
Student > Master | 5 | 11% |
Student > Doctoral Student | 4 | 9% |
Other | 10 | 22% |
Unknown | 5 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 29% |
Biochemistry, Genetics and Molecular Biology | 11 | 24% |
Agricultural and Biological Sciences | 7 | 16% |
Immunology and Microbiology | 4 | 9% |
Sports and Recreations | 1 | 2% |
Other | 3 | 7% |
Unknown | 6 | 13% |