Title |
The Role of the Tumor Stroma in Ovarian Cancer
|
---|---|
Published in |
Frontiers in oncology, May 2014
|
DOI | 10.3389/fonc.2014.00104 |
Pubmed ID | |
Authors |
Ben Davidson, Claes G. Trope, Reuven Reich |
Abstract |
The tumor microenvironment, consisting of stromal myofibroblasts, endothelial cells, and leukocytes, is growingly perceived to be a major contributor to the pathogenesis and disease progression in practically all cancer types. Stromal myofibroblasts produce angiogenic factors, proteases, growth factors, immune response-modulating proteins, anti-apoptotic proteins, and signaling molecules, and express surface receptors and respond to stimuli initiated in the tumor cells to establish a bi-directional communication network in the microenvironment to promote tumor cell invasion and metastasis. Many of these molecules are candidates for targeted therapy and the cancer stroma has been recently regarded as target for biological intervention. This review provides an overview of the biology and clinical role of the stroma in ovarian cancer. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
Romania | 1 | 50% |
France | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Germany | 1 | 1% |
Unknown | 76 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 16 | 21% |
Student > Ph. D. Student | 15 | 19% |
Student > Master | 9 | 12% |
Student > Doctoral Student | 6 | 8% |
Student > Bachelor | 4 | 5% |
Other | 7 | 9% |
Unknown | 21 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 19 | 24% |
Biochemistry, Genetics and Molecular Biology | 11 | 14% |
Medicine and Dentistry | 9 | 12% |
Immunology and Microbiology | 4 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Other | 7 | 9% |
Unknown | 25 | 32% |