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Ras/Raf/MEK/ERK Pathway Activation in Childhood Acute Lymphoblastic Leukemia and Its Therapeutic Targeting

Overview of attention for article published in Frontiers in oncology, June 2014
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Title
Ras/Raf/MEK/ERK Pathway Activation in Childhood Acute Lymphoblastic Leukemia and Its Therapeutic Targeting
Published in
Frontiers in oncology, June 2014
DOI 10.3389/fonc.2014.00160
Pubmed ID
Authors

Thomas Knight, Julie Anne Elizabeth Irving

Abstract

Deregulation of the Ras/Raf/MEK/extracellular signal-regulated kinase pathway is a common event in childhood acute lymphoblastic leukemia and is caused by point mutation, gene deletion, and chromosomal translocation of a vast array of gene types, highlighting its importance in leukemia biology. Pathway activation can be therapeutically exploited and may guide new therapies needed for relapsed acute lymphoblastic leukemia and other high risk subgroups.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 179 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
United States 1 <1%
Unknown 177 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 16%
Student > Bachelor 26 15%
Student > Master 24 13%
Researcher 16 9%
Student > Doctoral Student 13 7%
Other 17 9%
Unknown 55 31%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 45 25%
Agricultural and Biological Sciences 29 16%
Medicine and Dentistry 22 12%
Chemistry 5 3%
Immunology and Microbiology 5 3%
Other 13 7%
Unknown 60 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2014.
All research outputs
#22,963,239
of 25,604,262 outputs
Outputs from Frontiers in oncology
#16,204
of 22,741 outputs
Outputs of similar age
#209,566
of 243,391 outputs
Outputs of similar age from Frontiers in oncology
#72
of 98 outputs
Altmetric has tracked 25,604,262 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 22,741 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,391 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.