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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Mitochondrial Permeability Transition Pore and Cancer: Molecular Mechanisms Involved in Cell Death
|
|---|---|
| Published in |
Frontiers in oncology, November 2014
|
| DOI | 10.3389/fonc.2014.00302 |
| Pubmed ID | |
| Authors |
Massimo Bonora, Paolo Pinton |
| Abstract |
Since its discovery in the 1970s, the mitochondrial permeability transition (MPT) has been proposed to be a strategic regulator of cell death. Intense research efforts have focused on elucidating the molecular components of the MPT because this knowledge may help to better understand and treat various pathologies ranging from neurodegenerative and cardiac diseases to cancer. In the case of cancer, several studies have revealed alterations in the activity of the mitochondrial permeability transition pore (mPTP) and have determined its regulatory mechanism; these studies have also suggested that suppression of the activity of the mPTP, rather than its inactivation, commonly occurs in solid neoplasms. This review focuses on the most recent advances in understanding mPTP regulation in cancer and highlights the ability of the mPTP to impede the mechanisms of cell death. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 157 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Russia | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 154 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 17% |
| Student > Master | 26 | 17% |
| Researcher | 21 | 13% |
| Student > Bachelor | 18 | 11% |
| Student > Doctoral Student | 5 | 3% |
| Other | 17 | 11% |
| Unknown | 43 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 42 | 27% |
| Agricultural and Biological Sciences | 26 | 17% |
| Chemistry | 10 | 6% |
| Medicine and Dentistry | 9 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Other | 17 | 11% |
| Unknown | 47 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2022.
All research outputs
#17,690,023
of 25,932,719 outputs
Outputs from Frontiers in oncology
#8,212
of 22,839 outputs
Outputs of similar age
#228,287
of 370,632 outputs
Outputs of similar age from Frontiers in oncology
#49
of 97 outputs
Altmetric has tracked 25,932,719 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 22,839 research outputs from this source. They receive a mean Attention Score of 3.1. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 370,632 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.