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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair
|
|---|---|
| Published in |
Frontiers in oncology, November 2014
|
| DOI | 10.3389/fonc.2014.00318 |
| Pubmed ID | |
| Authors |
Akari Minami, Atsuko Nakanishi, Yasunori Ogura, Yasuko Kitagishi, Satoru Matsuda |
| Abstract |
Genomic instability finally induces cell death or apoptosis. The tumor suppressor, phosphatase and tensin homolog on chromosome 10 (PTEN), is a dual-specificity phosphatase, which has protein phosphatase activity and lipid phosphatase activity that antagonizes PI3K activity. Cells that lack PTEN have constitutively higher levels of PIP3 and activated downstream PI3K/AKT targets. BRCA1, a well-known breast cancer tumor suppressor, is to associate with breast cancer risk and genetic susceptibility. Many studies have demonstrated that PTEN, as well as BRCA1, plays a critical role in DNA damage responses. The BRCA1 functionally cooperates with PTEN and might be an essential blockage in the development of several tumors. Actually, the PTEN and BRCA1 genes are recognized as one of the most frequently deleted and/or mutated in many human cancers. The PI3K/AKT pathway is constitutively active in BRCA1-defective human cancer cells. Loss or decrease of these PTEN or BRCA1 function, by either mutation or reduced expression, has a role in various tumor developments. This review summarizes recent findings of the function of BRCA1 and PTEN involved in genomic stability and cancer cell signaling. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 108 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 25% |
| Researcher | 13 | 12% |
| Student > Master | 12 | 11% |
| Student > Bachelor | 12 | 11% |
| Student > Doctoral Student | 9 | 8% |
| Other | 20 | 18% |
| Unknown | 16 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 28 | 26% |
| Agricultural and Biological Sciences | 27 | 25% |
| Medicine and Dentistry | 17 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Unspecified | 4 | 4% |
| Other | 8 | 7% |
| Unknown | 21 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 October 2015.
All research outputs
#15,169,543
of 25,374,647 outputs
Outputs from Frontiers in oncology
#4,543
of 22,416 outputs
Outputs of similar age
#136,162
of 273,209 outputs
Outputs of similar age from Frontiers in oncology
#41
of 99 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 22,416 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,209 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.