Title |
Neuropilin-1 as Therapeutic Target for Malignant Melanoma
|
---|---|
Published in |
Frontiers in oncology, June 2015
|
DOI | 10.3389/fonc.2015.00125 |
Pubmed ID | |
Authors |
Grazia Graziani, Pedro M. Lacal |
Abstract |
Neuropilin-1 (NRP-1) is a transmembrane glycoprotein that acts as a co-receptor for various members of the vascular endothelial growth factor (VEGF) family. Its ability to bind or modulate the activity of a number of other extracellular ligands, such as class 3 semaphorins, TGF-β, HGF, FGF, and PDGF, has suggested the involvement of NRP-1 in a variety of physiological and pathological processes. Actually, this co-receptor has been implicated in axon guidance, angiogenesis, and immune responses. NRP-1 is also expressed in a variety of cancers (prostate, lung, pancreatic, or colon carcinoma, melanoma, astrocytoma, glioblastoma, and neuroblastoma), suggesting a critical role in tumor progression. Moreover, a growing amount of evidence indicates that NRP-1 might display important functions independently of other VEGF receptors. In particular, in the absence of VEGFR-1/2, NRP-1 promotes melanoma invasiveness, through the activation of selected integrins, by stimulating VEGF-A and metalloproteinases secretion and modulating specific signal transduction pathways. This review is focused on the role of NRP-1 in melanoma aggressiveness and on the evidence supporting its use as target of therapies for metastatic melanoma. |
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Country | Count | As % |
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United Kingdom | 4 | 67% |
Switzerland | 1 | 17% |
Unknown | 1 | 17% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 1 | <1% |
United States | 1 | <1% |
Italy | 1 | <1% |
Unknown | 115 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 27 | 23% |
Researcher | 22 | 19% |
Student > Bachelor | 12 | 10% |
Student > Master | 9 | 8% |
Student > Postgraduate | 8 | 7% |
Other | 12 | 10% |
Unknown | 28 | 24% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 24 | 20% |
Medicine and Dentistry | 17 | 14% |
Biochemistry, Genetics and Molecular Biology | 16 | 14% |
Immunology and Microbiology | 16 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 6% |
Other | 9 | 8% |
Unknown | 29 | 25% |