↓ Skip to main content

Modeling Combined Chemotherapy and Particle Therapy for Locally Advanced Pancreatic Cancer

Overview of attention for article published in Frontiers in oncology, July 2015
Altmetric Badge

Mentioned by

twitter
2 X users

Citations

dimensions_citation
26 Dimensions

Readers on

mendeley
40 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Modeling Combined Chemotherapy and Particle Therapy for Locally Advanced Pancreatic Cancer
Published in
Frontiers in oncology, July 2015
DOI 10.3389/fonc.2015.00145
Pubmed ID
Authors

Marco Durante, Francesco Tommasino, Shigeru Yamada

Abstract

Pancreatic ductal adenocarcinoma is the only cancer for which deaths are predicted to increase in 2014 and beyond. Combined radiochemotherapy protocols using gemcitabine and hypofractionated X-rays are ongoing in several clinical trials. Recent results indicate that charged particle therapy substantially increases local control of resectable and unresectable pancreas cancer, as predicted from previous radiobiology studies considering the high tumor hypoxia. Combination with chemotherapy improves the overall survival (OS). We compared published data on X-ray and charged particle clinical results with or without adjuvant chemotherapy calculating the biological effective dose. We show that chemoradiotherapy with protons or carbon ions results in 1 year OS significantly higher than those obtained with other treatment schedules. Further hypofractionation using charged particles may result in improved local control and survival. A comparative clinical trial using the standard X-ray scheme vs. the best current standard with carbon ions is crucial and may open new opportunities for this deadly disease.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 20%
Other 5 13%
Researcher 5 13%
Professor 5 13%
Student > Master 3 8%
Other 5 13%
Unknown 9 23%
Readers by discipline Count As %
Medicine and Dentistry 9 23%
Agricultural and Biological Sciences 4 10%
Physics and Astronomy 4 10%
Engineering 2 5%
Economics, Econometrics and Finance 1 3%
Other 6 15%
Unknown 14 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2015.
All research outputs
#20,924,905
of 26,587,745 outputs
Outputs from Frontiers in oncology
#9,849
of 23,330 outputs
Outputs of similar age
#191,411
of 276,935 outputs
Outputs of similar age from Frontiers in oncology
#47
of 72 outputs
Altmetric has tracked 26,587,745 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 23,330 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,935 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.