Leonardo Marques da Fonseca, Vanessa Amil da Silva, Leonardo Freire-de-Lima, José Osvaldo Previato, Lucia Mendonça-Previato, Márcia Alves Marques Capella
Abstract
The expression of unusual glycan structures is a hallmark of cancer progression, and their functional roles in cancer biology have been extensively investigated in epithelial-to-mesenchymal transition (EMT) models. EMT is a physiological process involved in embryonic development and wound healing. It is characterized by loss of epithelial cell polarity and cell adhesion, permitting cell migration, and thus formation of new epithelia. However, this process is unwanted when occurring outside their physiological limit, resulting in fibrosis of organs and progression of cancer and metastasis. Several studies observed that EMT is related to the acquisition of multidrug resistance (MDR) phenotype, a condition in which cancer cells acquire resistance to multiple different drugs, which has virtually nothing in common. However, although some studies suggested interplay between these two apparently distinct phenomena, almost nothing is known about this possible relationship. A common pathway to them is the need for glycosylation, a post-translational modification that can alter biological function. Thus, this review intends to compile the main facts obtained until now in these two areas, as an effort to unravel the relationship between EMT and MDR.
Pharmacology, Toxicology and Pharmaceutical Science
5
8%
Medicine and Dentistry
5
8%
Chemistry
3
5%
Other
4
7%
Unknown
19
31%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2016.
All research outputs
#20,829,511
of 25,593,129 outputs
Outputs from Frontiers in oncology
#11,454
of 22,728 outputs
Outputs of similar age
#284,769
of 369,191 outputs
Outputs of similar age from Frontiers in oncology
#46
of 68 outputs
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We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.
