Title |
Aberrant Promoter Hypomethylation in CLL: Does It Matter for Disease Development?
|
---|---|
Published in |
Frontiers in oncology, August 2016
|
DOI | 10.3389/fonc.2016.00182 |
Pubmed ID | |
Authors |
Garland Michael Upchurch, Staci L. Haney, Rene Opavsky |
Abstract |
Over the last 30 years, studies of aberrant DNA methylation in hematologic malignancies have been dominated by the primary focus of understanding promoter hypermethylation. These efforts not only resulted in a better understanding of the basis of epigenetic silencing of tumor suppressor genes but also resulted in approval of hypomethylating agents for the treatment of several malignancies, such as myelodysplastic syndrome and acute myeloid leukemia. Recent advances in global methylation profiling coupled with the use of mouse models suggest that aberrant promoter hypomethylation is also a frequent event in hematologic malignancies, particularly in chronic lymphocytic leukemia (CLL). Promoter hypomethylation affects gene expression and, therefore, may play an important role in disease pathogenesis. Here, we review recent findings and discuss the potential involvement of aberrant promoter hypomethylation in CLL. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Belgium | 1 | 25% |
France | 1 | 25% |
Switzerland | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 24% |
Student > Bachelor | 4 | 19% |
Professor | 2 | 10% |
Student > Doctoral Student | 1 | 5% |
Student > Master | 1 | 5% |
Other | 3 | 14% |
Unknown | 5 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 24% |
Agricultural and Biological Sciences | 5 | 24% |
Medicine and Dentistry | 3 | 14% |
Business, Management and Accounting | 1 | 5% |
Nursing and Health Professions | 1 | 5% |
Other | 1 | 5% |
Unknown | 5 | 24% |