Title |
Mitochondrial and Oxidative Stress-Mediated Activation of Protein Kinase D1 and Its Importance in Pancreatic Cancer
|
---|---|
Published in |
Frontiers in oncology, March 2017
|
DOI | 10.3389/fonc.2017.00041 |
Pubmed ID | |
Authors |
Heike Döppler, Peter Storz |
Abstract |
Due to alterations in their metabolic activity and decreased mitochondrial efficiency, cancer cells often show increased generation of reactive oxygen species (ROS), but at the same time, to avoid cytotoxic signaling and to facilitate tumorigenic signaling, have mechanism in place that keep ROS in check. This requires signaling molecules that convey increases in oxidative stress to signal to the nucleus to upregulate antioxidant genes. Protein kinase D1 (PKD1), the serine/threonine kinase, is one of these ROS sensors. In this mini-review, we highlight the mechanisms of how PKD1 is activated in response to oxidative stress, so far known downstream effectors, as well as the importance of PKD1-initiated signaling for development and progression of pancreatic cancer. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 23% |
Student > Master | 4 | 13% |
Researcher | 3 | 10% |
Student > Bachelor | 3 | 10% |
Student > Doctoral Student | 2 | 7% |
Other | 2 | 7% |
Unknown | 9 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 12 | 40% |
Agricultural and Biological Sciences | 5 | 17% |
Unspecified | 1 | 3% |
Immunology and Microbiology | 1 | 3% |
Psychology | 1 | 3% |
Other | 3 | 10% |
Unknown | 7 | 23% |